Document Detail

Myotonic dystrophy: opportunities for prenatal prediction.
MedLine Citation:
PMID:  1171415     Owner:  NLM     Status:  MEDLINE    
Prenatal prediction of the inheritance of myotonic dystrophy in a family with affected individuals feasible in special cases when analysis of linkage to the secretor gene (determing ABH substances) can be carried out. We report a large kindred having multiple members affected with variable degrees of severity of myotonic dystrophy and having several matings for which linkage analysis is feasible. Even though this approach is not applicable for most families and although the process of genetic recombination complicates the analysis, in individual cases the use of linkage in prenatal or postnatal prediction of myotonic dystrophy may be very helpful for early diagnosis, more precise genetic counseling, and family planning.
H G Schrott; G S Omenn
Related Documents :
20928905 - Confirmation that the specific sslp microsatellite allele 4qa161 segregates with fascio...
10999845 - Heterogeneity of nuclear lamin a mutations in dunnigan-type familial partial lipodystro...
1684565 - Molecular deletion patterns in families from southern france with duchenne/becker muscu...
21089175 - Gene diagnosis of oculopharyngeal muscular dystrophy in a chinese family by a genescan ...
16505055 - Microarray-based mutation detection and phenotypic characterization of patients with le...
15910325 - Genetic entities and mating system in hermaphroditic fucus spiralis and its close dioec...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  25     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  789-91     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromosome Mapping
Genetic Counseling
Linkage (Genetics)
Myotonic Dystrophy / diagnosis*,  genetics,  prevention & control
Prenatal Diagnosis / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Response of generalized penicillin epilepsy in the cat to ethosuximide and diphenylhydantoin.
Next Document:  Acute overdose with levodopa. Clinical and biochemical consequences.