Document Detail

Myotonic dystrophy and cardiac disorders.
MedLine Citation:
PMID:  11294088     Owner:  NLM     Status:  MEDLINE    
Myotonic dystrophy (MD) is a multisystem disease affecting numerous organs and systems. Cardiac involvement is frequent. Sudden death, due to fatal cardiac rhythm and conduction disturbances occurs in 30% of patients with MD. The aim of this study was to assess the possibilities and methods of early detection of myocardial and conduction system disturbances. ECG, 24-hr Holter monitoring, echocardiography and electrophysiologic studies of the conduction system (electrophysiologic study) were carried out in 45 patients. Analysis of late ventricular potentials was done in 36 patients. Genetic studies revealed multiplication of CTG triplets in all patients. Cardiological abnormalities were detected in 89% of our patients. Disturbances of intraventricular conduction with prolongation of HV interval were most frequent (72%). Electrophysiologic study was the most sensitive method for detecting heart involvement in MD (positive findings in 87% patients). Abnormal findings were also discovered by Holter monitoring (64%), ECG (58%), analysis of late ventricular potentials (55%) and by echocardiography in 46% patients. The results of this study indicate a high rate of cardiac involvement in MD.
V Rakocević-Stojanović; M Grujić; P Seferović; D Lavrnić; S Pavlovic; V Nesković; S Romac; S Apostolski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Panminerva medica     Volume:  42     ISSN:  0031-0808     ISO Abbreviation:  Panminerva Med     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-04-10     Completed Date:  2001-04-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421110     Medline TA:  Panminerva Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Institute of Neurology, Dr. Subotića 6, 11000 Belgrade, Yugoslavia.
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MeSH Terms
Heart Diseases / etiology*
Middle Aged
Myotonic Dystrophy / complications*,  genetics,  physiopathology
Trinucleotide Repeats
Ventricular Function, Left

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