Document Detail


Myotonic dystrophy: calcium-dependent phosphatidic acid synthesis in erythrocytes.
MedLine Citation:
PMID:  7305303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently it was reported that calcium-dependent phosphatidic acid synthesis in erythrocyte of patients with myotonic muscular dystrophy (MyD) is markedly impaired when compared to that in control subjects. Using 32P-loaded erythrocytes, we found no significant difference in the levels of 32P-phosphatidic acid synthesized after exposure to calcium and its ionophore A23187 between patients with MyD and controls. In a batch experiment typical of the experiments with 32P, and a twofold increase of phosphatidic acid in both groups was determined by inorganic phosphate measurements. Thus, the specific activity of the 32P-phosphatidic acid increased four- to five-fold in response to calcium Analyses of 32P-polyphosphoinositide breakdown in ghosts and in adenosine triphosphate-depleted erythrocytes also appeared normal for patients with myotonic muscular dystrophy. Possible discrepancies between the results presented here and those reported previously are discussed.
Authors:
R B Moore; S H Appel; G A Plishker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  10     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Calcium / blood*
Erythrocyte Membrane / metabolism
Erythrocytes / metabolism*
Humans
Hydrolysis
Muscular Dystrophies / blood*
Phosphatidic Acids / blood*
Chemical
Reg. No./Substance:
0/Phosphatidic Acids; 56-65-5/Adenosine Triphosphate; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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