| Myositis associated with the decline of thyroid hormone levels in thyrotoxicosis: a syndrome? | |
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MedLine Citation:
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PMID: 19916866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Background: Musculoskeletal complaints are common in patients with thyroid dysfunction. Both thyrotoxic and hypothyroid myopathy have been well described, and there are distinct presentations, laboratory findings, and clinical outcomes between the two groups. Myopathy has also been reported in hyperthyroid patients only after beginning treatment, suggesting that relative hypothyroidism may also contribute to musculoskeletal disease. A confounding factor in these cases was that these patients were on antithyroid drugs that may also have direct effects on the muscle, irrespective of the rate of decline in thyroid hormone levels. Summary: We report a patient with Graves' disease who developed myalgias with elevated creatine kinase levels after total thyroidectomy. Addition of triiodothyronine quickly resolved her symptoms and creatine kinase levels, whereas discontinuation of triiodothyronine, despite having normal to elevated total thyroxine levels, led to a relapse. Conclusion: Myositis after correction of thyrotoxicosis may constitute a syndrome that should be assessed for in hyperthyroid patients complaining of myalgias after starting treatment. |
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Authors:
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Duha Shaheen; Caroline S Kim |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 19 ISSN: 1557-9077 ISO Abbreviation: Thyroid Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States |
Other Details:
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Languages: eng Pagination: 1413-7 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center , Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Creatine Kinase
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blood Female Graves Disease / complications* Humans Myositis / etiology* Syndrome Thyroid Hormones / metabolism* Thyroidectomy Thyrotoxicosis / complications* Thyroxine / blood Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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