Document Detail

Myositis associated with the decline of thyroid hormone levels in thyrotoxicosis: a syndrome?
MedLine Citation:
PMID:  19916866     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Musculoskeletal complaints are common in patients with thyroid dysfunction. Both thyrotoxic and hypothyroid myopathy have been well described, and there are distinct presentations, laboratory findings, and clinical outcomes between the two groups. Myopathy has also been reported in hyperthyroid patients only after beginning treatment, suggesting that relative hypothyroidism may also contribute to musculoskeletal disease. A confounding factor in these cases was that these patients were on antithyroid drugs that may also have direct effects on the muscle, irrespective of the rate of decline in thyroid hormone levels.
SUMMARY: We report a patient with Graves' disease who developed myalgias with elevated creatine kinase levels after total thyroidectomy. Addition of triiodothyronine quickly resolved her symptoms and creatine kinase levels, whereas discontinuation of triiodothyronine, despite having normal to elevated total thyroxine levels, led to a relapse.
CONCLUSION: Myositis after correction of thyrotoxicosis may constitute a syndrome that should be assessed for in hyperthyroid patients complaining of myalgias after starting treatment.
Duha Shaheen; Caroline S Kim
Related Documents :
13523396 - Hyperthyroidism; diagnosis by failure of triiodothyronine to suppress uptake of iodine ...
12970276 - Thyrotropin receptor autoantibodies are associated with continued thyrotropin suppressi...
1932406 - The trh stimulation test in alzheimer's disease and major depression: relationship to c...
21123016 - Hepatic arterial perfusion increases in the early stage of severe acute pancreatitis pa...
23197906 - Analysis of colonization and genotyping of the exotoxins of staphylococcus aureus in pa...
17055636 - Nerve growth factor serum concentrations rise after successful cognitive-behavioural th...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  19     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-03-08     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1413-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Creatine Kinase / blood
Graves Disease / complications*
Myositis / etiology*
Thyroid Hormones / metabolism*
Thyrotoxicosis / complications*
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Thyroid Hormones; 06LU7C9H1V/Triiodothyronine; EC Kinase; Q51BO43MG4/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Congenital Hypothyroidism and Late-Onset Goiter: Identification and Characterization of a Novel Muta...
Next Document:  Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513.