Document Detail

Myosin light chain kinases and phosphatase in mitosis and cytokinesis.
MedLine Citation:
PMID:  21396909     Owner:  NLM     Status:  MEDLINE    
At mitosis, cells undergo drastic alterations in morphology and cytoskeletal organization including cell rounding during prophase, mitotic spindle assembly during prometaphase and metaphase, chromatid segregation in anaphase, and cytokinesis during telophase. It is well established that myosin II is a motor responsible for cytokinesis. Recent reports have indicated that myosin II is also involved in spindle assembly and karyokinesis. In this review, we summarize current understanding of the functions of myosin II in mitosis and cytokinesis of higher eukaryotes, and discuss the roles of possible upstream molecules that control myosin II in these mitotic events.
Fumio Matsumura; Yoshihiko Yamakita; Shigeko Yamashiro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-03-21
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  510     ISSN:  1096-0384     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-13     Completed Date:  2011-08-09     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Molecular Biology & Biochemistry, Rutgers, Piscataway, NJ 08854, USA.
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MeSH Terms
Myosin Type II / metabolism
Myosin-Light-Chain Kinase / metabolism*
Myosin-Light-Chain Phosphatase / metabolism*
Grant Support
R01 CA042742/CA/NCI NIH HHS; R01 CA042742-25/CA/NCI NIH HHS; R01CA42742/CA/NCI NIH HHS
Reg. No./Substance:
EC Kinase; EC Phosphatase; EC 3.6.1.-/Myosin Type II

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