| Myosin heavy chain synthesis during the progression of chronic tachycardia induced heart failure in rabbits. | |
| | |
MedLine Citation:
|
PMID: 9538937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chronic tachycardia causes LV dilatation and dysfunction, with no hypertrophy. However, the contributing mechanisms responsible for the left ventricular (LV) remodeling in the absence of myocardial growth in this model of heart failure remain unclear. Therefore, the goal of the present study was to serially examine changes in LV function, steady state myosin heavy chain (MHC) mRNA levels, in vivo synthesis rates, and abundance with the progression of chronic tachycardia induced heart failure. Adult rabbits (3.5-4.5 kg) were studied after one, two, or three weeks of pacing ventricular tachycardia (VT; 400 bpm) and in controls (n = 6 for all groups). LV fractional shortening was reduced by 30% at week one and by over 50% at week three of chronic VT. End-diastolic dimension (EDD) increased at week two compared to controls (1.66 +/- 0.10 vs 1.35 +/- 0.11 cm, p < 0.05) and increased further at week three of VT (1.70 +/- 0.06 cm, p < 0.05). The progressive changes in LV geometry and function with chronic VT were not associated with concomitant time dependent changes in LV mass or MHC mRNA levels. In contrast, MHC fractional synthesis rates increased and reached statistical significance at week three of VT compared to controls (8.3 +/- 0.8 vs 5.5 +/- 0.5%/day, p < 0.05). Despite the stable or increased MHC protein synthesis rates, there was no change in MHC protein abundance at any point during the progression of VT induced heart failure, implicating enhanced MHC protein degradation. Thus, this study demonstrated that a contributory mechanism for the LV remodeling and lack of myocardial growth, which occurs with VT induced heart failure, is enhanced contractile protein degradative processes. |
| | |
Authors:
|
D M Eble; J D Walker; A M Samarel; F G Spinale |
Related Documents
:
|
14639017 - Correlation of connexin43 expression and late ventricular potentials in nonischemic dil... 7699737 - Antiarrhythmic effects of eicosapentaenoic acid during myocardial infarction--enhanced ... 8435927 - Idiopathic verapamil-sensitive sustained left ventricular tachycardia. 19022157 - Action potential dynamics explain arrhythmic vulnerability in human heart failure: a cl... 1869327 - Paucity of risk factors in women with angina and normal coronary angiograms. 12602717 - Fatal spontaneous retroperitoneal hematoma secondary to enoxaparin. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Basic research in cardiology Volume: 93 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1998 Feb |
Date Detail:
|
Created Date: 1998-05-19 Completed Date: 1998-05-19 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 50-5 Citation Subset: IM |
Affiliation:
|
Cardiovascular Institute, Loyola University Chicago, Maywood, IL 60153, USA. deble@luc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blotting, Northern Cardiac Pacing, Artificial / adverse effects Chronic Disease Disease Models, Animal Disease Progression Echocardiography Follow-Up Studies Heart Failure / etiology, metabolism* Myocardium / metabolism* Myosin Heavy Chains / biosynthesis*, genetics RNA, Messenger / metabolism Rabbits Tachycardia, Ventricular / complications*, metabolism Ventricular Function, Left |
| Grant Support | |
ID/Acronym/Agency:
|
F32HL09611/HL/NHLBI NIH HHS; HL45024/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Myosin Heavy Chains; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of metabolic responses to low-flow ischemia in intact pig hearts and isolated blood...
Next Document: Measurement of left ventricular maximal isovolumetric pressure in rats: effects of antihypertensive ...