Document Detail


Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation.
MedLine Citation:
PMID:  20797537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reorganization of the actin cytoskeleton is essential for synaptic plasticity and memory formation. Presently, the mechanisms that trigger actin dynamics during these brain processes are poorly understood. In this study, we show that myosin II motor activity is downstream of LTP induction and is necessary for the emergence of specialized actin structures that stabilize an early phase of LTP. We also demonstrate that myosin II activity contributes importantly to an actin-dependent process that underlies memory consolidation. Pharmacological treatments that promote actin polymerization reversed the effects of a myosin II inhibitor on LTP and memory. We conclude that myosin II motors regulate plasticity by imparting mechanical forces onto the spine actin cytoskeleton in response to synaptic stimulation. These cytoskeletal forces trigger the emergence of actin structures that stabilize synaptic plasticity. Our studies provide a mechanical framework for understanding cytoskeletal dynamics associated with synaptic plasticity and memory formation.
Authors:
Christopher S Rex; Cristin F Gavin; Maria D Rubio; Eniko A Kramar; Lulu Y Chen; Yousheng Jia; Richard L Huganir; Nicholas Muzyczka; Christine M Gall; Courtney A Miller; Gary Lynch; Gavin Rumbaugh
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  67     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-09-27     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-17     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism*
Animals
Dendritic Spines / drug effects,  physiology
Excitatory Postsynaptic Potentials / drug effects
Hippocampus / drug effects,  physiology
Long-Term Potentiation / drug effects,  physiology*
Male
Memory / drug effects,  physiology*
Models, Neurological
Myosin Light Chains / metabolism
Myosins / metabolism
Neuronal Plasticity / drug effects,  physiology
Nonmuscle Myosin Type IIB / antagonists & inhibitors,  metabolism*
Phosphorylation
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate / metabolism
Synapses / drug effects,  physiology*
Time Factors
Grant Support
ID/Acronym/Agency:
AG00096/AG/NIA NIH HHS; MH083396/MH/NIMH NIH HHS; NINDS 045540//PHS HHS; NS05182/NS/NINDS NIH HHS; NS064079/NS/NINDS NIH HHS; NS45260/NS/NINDS NIH HHS; R00 DA024761/DA/NIDA NIH HHS; R01 NS064079/NS/NINDS NIH HHS; R01 NS064079-03/NS/NINDS NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Actins; 0/Myosin Light Chains; 0/Receptors, N-Methyl-D-Aspartate; EC 3.6.1.-/Nonmuscle Myosin Type IIB; EC 3.6.4.1/Myosins
Comments/Corrections

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