Document Detail


Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila.
MedLine Citation:
PMID:  17981139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Remodeling epithelia is a primary driver of morphogenesis. Here, we report a central role of myosin II in regulating several aspects of complex epithelial architecture in the Drosophila eye imaginal disc. The epithelial indentation of the morphogenetic furrow is established from a pattern of myosin II activation defined by the developmental signals Hedgehog and Decapentaplegic. More generally, patterned myosin activation can control diverse three-dimensional epithelial sculpting. We have developed a technique to image eye disc development in real time, and we show that myosin II also regulates higher-order organization of cells in the plane of the epithelium. This includes the clustering of cells into ommatidial units and their subsequent coordinated rotation. This later clustering function of myosin II depends on EGF receptor signaling. Our work implies that regulation of the actomyosin cytoskeleton can control morphogenesis by regulating both individual cell shapes and their complex two-dimensional arrangement within epithelia.
Authors:
Luis M Escudero; Marcus Bischoff; Matthew Freeman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  13     ISSN:  1534-5807     ISO Abbreviation:  Dev. Cell     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-02-14     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  717-29     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning
Compound Eye, Arthropod / growth & development,  metabolism*
Cytoskeleton / physiology
Drosophila / growth & development,  physiology*
Drosophila Proteins / physiology*
Epithelium / growth & development,  physiology
Larva
Morphogenesis
Myosin Type II / physiology*
Signal Transduction
Grant Support
ID/Acronym/Agency:
MC_U105178780//Medical Research Council
Chemical
Reg. No./Substance:
0/Drosophila Proteins; EC 3.6.1.-/Myosin Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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