| Myopic discounting of future rewards after medial orbitofrontal damage in humans. | |
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MedLine Citation:
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PMID: 21147982 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Choices are often intertemporal, requiring tradeoff of short-term and long-term outcomes. In such contexts, humans may prefer small rewards delivered immediately to larger rewards delivered after a delay, reflecting temporal discounting (TD) of delayed outcomes. The medial orbitofrontal cortex (mOFC) is consistently activated during intertemporal choice, yet its role remains unclear. Here, patients with lesions in the mOFC (mOFC patients), control patients with lesions outside the frontal lobe, and healthy individuals chose hypothetically between small-immediate and larger-delayed rewards. The type of reward varied across three TD tasks, including both primary (food) and secondary (money and discount vouchers) rewards. We found that damage to mOFC increased significantly the preference for small-immediate over larger-delayed rewards, resulting in steeper TD of future rewards in mOFC patients compared with the control groups. This held for both primary and secondary rewards. All participants, including mOFC patients, were more willing to wait for delayed money and discount vouchers than for delayed food, suggesting that mOFC patients' (impatient) choices were not due merely to poor motor impulse control or consideration of the goods at stake. These findings provide the first evidence in humans that mOFC is necessary for valuation and preference of delayed rewards for intertemporal choice. |
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Authors:
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Manuela Sellitto; Elisa Ciaramelli; Giuseppe di Pellegrino |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-01-07 Revised Date: 2011-06-07 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 16429-36 Citation Subset: IM |
Affiliation:
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Dipartimento di Psicologia, Università di Bologna, 40127 Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Area Under Curve Brain Injuries / complications, pathology* Choice Behavior / physiology* Cognition Disorders / etiology, pathology* Female Frontal Lobe / blood supply, pathology* Humans Image Processing, Computer-Assisted Impulsive Behavior / etiology Magnetic Resonance Imaging / methods Male Middle Aged Neuropsychological Tests Oxygen / blood Reinforcement Schedule Reward* Time Factors |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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J Neurosci. 2011 Apr 20;31(16):5889-90
[PMID:
21508212
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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