Document Detail


Myopia associated with hyperbaric oxygen therapy.
MedLine Citation:
PMID:  8843129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hyperbaric oxygen therapy (HBOT) involves exposing patients to elevated oxygen pressures and concentrations for the treatment of soft tissue degenerative diseases. As side effects, some patients experience cataract development and/or a significant increase in myopia. SUBJECTS: Eight subjects participated in this project. All were receiving HBOT for health problems. METHODS: For all subjects, acuities and refractive error corrections were measured before and after HBOT sessions at the beginning, midpoint, and end of therapy. For four subjects, A-scan ultrasound and corneal curvature measurements were also made before and after selected HBOT sessions. In addition, susceptibility to free radical damage and indicators of actual damage were measured by blood analyses. During the first half of HBOT therapy, four subjects took placebo tablets; during the second half, antioxidant supplements were given. RESULTS: No subject showed significant acuity or refractive error changes produced by single HBOT sessions. Two of the 8 subjects showed significant increases in myopia over the 20 session course of HBOT. No corresponding changes were found in the ultrasound, corneal curvature, or blood analysis data. DISCUSSION: Theoretically, the increases in myopia could have been caused by lenticular refractive index changes resulting from oxidative damage to lens proteins. However, the biochemical assays used in this project did not predict which subjects were susceptible to increased myopia, nor did they demonstrate elevated levels of free radical activity in a subject who did experience an increase in myopia.
Authors:
M E Ross; D P Yolton; R L Yolton; K D Hyde
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Optometry and vision science : official publication of the American Academy of Optometry     Volume:  73     ISSN:  1040-5488     ISO Abbreviation:  Optom Vis Sci     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904931     Medline TA:  Optom Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  487-94     Citation Subset:  IM    
Affiliation:
College of Optometry, Pacific University, Forest Grove, Oregon, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antioxidants / administration & dosage
Colon / pathology
Cornea / anatomy & histology
Female
Free Radicals
Humans
Hyperbaric Oxygenation / adverse effects*
Larynx / pathology
Male
Mandible / pathology
Middle Aged
Myopia / etiology*
Necrosis
Radiation Injuries / etiology,  therapy
Rectum / pathology
Refraction, Ocular
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radicals

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