Document Detail

Myopathy associated with anti-signal recognition peptide antibodies: clinical heterogeneity contrasts with stereotyped histopathology.
MedLine Citation:
PMID:  17143889     Owner:  NLM     Status:  MEDLINE    
We report three patients with anti-signal recognition particle antibodies who had different presenting clinical pictures, mimicking acute polymyositis, limb-girdle muscular dystrophy, and acute rhabdomyolysis. Muscle biopsies typically showed necrotizing myopathy with little or no inflammation and deposits of membrane attack complex (C5b-9) in endomysial capillaries. The clinical course was severe in two patients and mild in one. The combination of corticosteroid with either an immunosuppressive agent or intravenous immunoglobulins was required to improve the condition of these patients.
Dalia Dimitri; Chantal Andre; Jacques Roucoules; Hassan Hosseini; René-Louis Humbel; François-Jérôme Authier
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  35     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-15     Completed Date:  2007-04-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-95     Citation Subset:  IM    
Centre de Référence des Maladies Neuromusculaires, Service d'Histologie, CHU Henri Mondor, 51 Avenue du Marécal de Lattre de Tassigny, 94010 Créteil, France.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Autoantibodies / blood*
Biological Markers / analysis,  metabolism
Complement Membrane Attack Complex / immunology,  metabolism
Diagnosis, Differential
Disease Progression
Immunosuppressive Agents / therapeutic use
Middle Aged
Muscle Fibers, Skeletal / immunology,  metabolism,  pathology
Muscle, Skeletal / immunology*,  pathology*,  physiopathology
Muscular Diseases / diagnosis*,  immunology*,  physiopathology
Muscular Dystrophies, Limb-Girdle / diagnosis,  immunology,  physiopathology
Polymyositis / diagnosis,  immunology,  physiopathology
Predictive Value of Tests
Rhabdomyolysis / diagnosis,  immunology,  physiopathology
Signal Recognition Particle / immunology*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Autoantibodies; 0/Biological Markers; 0/Complement Membrane Attack Complex; 0/Immunosuppressive Agents; 0/Signal Recognition Particle

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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