| Myopathy associated with anti-signal recognition peptide antibodies: clinical heterogeneity contrasts with stereotyped histopathology. | |
| | |
MedLine Citation:
|
PMID: 17143889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report three patients with anti-signal recognition particle antibodies who had different presenting clinical pictures, mimicking acute polymyositis, limb-girdle muscular dystrophy, and acute rhabdomyolysis. Muscle biopsies typically showed necrotizing myopathy with little or no inflammation and deposits of membrane attack complex (C5b-9) in endomysial capillaries. The clinical course was severe in two patients and mild in one. The combination of corticosteroid with either an immunosuppressive agent or intravenous immunoglobulins was required to improve the condition of these patients. |
| | |
Authors:
|
Dalia Dimitri; Chantal Andre; Jacques Roucoules; Hassan Hosseini; René-Louis Humbel; François-Jérôme Authier |
Related Documents
:
|
21161709 - Migraine attacks, aura, and polycythemia: a vasculoneural pathogenesis? 8794729 - Vertical duane's retraction syndrome. 8827899 - Cardiorespiratory function in duchenne and becker muscular dystrophy. 3087199 - Rett syndrome--search for genetic markers. 9677159 - Activity of a ritonavir plus saquinavir-containing regimen in patients with virologic e... 2790399 - Reflex sympathetic dystrophy (algoneurodystrophy): temperature studies in the upper limb. 1190699 - Hl-a27 and arthritis. 6568949 - Neurovascular disturbances in headache patients. 7918069 - Identification of a subgroup of myelodysplastic patients with a neutrophil stimulation-... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Muscle & nerve Volume: 35 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-02-15 Completed Date: 2007-04-19 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
|
Languages: eng Pagination: 389-95 Citation Subset: IM |
Affiliation:
|
Centre de Référence des Maladies Neuromusculaires, Service d'Histologie, CHU Henri Mondor, 51 Avenue du Marécal de Lattre de Tassigny, 94010 Créteil, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use Adult Autoantibodies / blood* Biological Markers / analysis, metabolism Biopsy Complement Membrane Attack Complex / immunology, metabolism Diagnosis, Differential Disease Progression Female Humans Immunosuppressive Agents / therapeutic use Male Middle Aged Muscle Fibers, Skeletal / immunology, metabolism, pathology Muscle, Skeletal / immunology*, pathology*, physiopathology Muscular Diseases / diagnosis*, immunology*, physiopathology Muscular Dystrophies, Limb-Girdle / diagnosis, immunology, physiopathology Phenotype Polymyositis / diagnosis, immunology, physiopathology Predictive Value of Tests Rhabdomyolysis / diagnosis, immunology, physiopathology Signal Recognition Particle / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Autoantibodies; 0/Biological Markers; 0/Complement Membrane Attack Complex; 0/Immunosuppressive Agents; 0/Signal Recognition Particle |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tandem duplication of DMD exon 18 associated with epilepsy, macroglossia, and endocrinologic abnorma...
Next Document: Epidemiology of cauda equina and conus medullaris lesions.