Document Detail


MyomiRs-133a/b turn off the heat.
MedLine Citation:
PMID:  23196844     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.
Authors:
Jan-Wilhelm Kornfeld; Jens C Brüning
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature cell biology     Volume:  14     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1248-9     Citation Subset:  IM    
Affiliation:
Max Planck Institute for Neurological Research, Gleueler Street 50a, 50931 Köln, Germany, and the Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Zülpicher Street 47a, 50674 Köln, Germany.
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