Document Detail

Myometrial hyperplasia in pediatric, adolescent, and young adult uteri.
MedLine Citation:
PMID:  14597019     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate if myometrial hyperplasia is a congenital variation in myometrial differentiation, or an acquired structural disorder of the myometrium, this study evaluated whether myometrial hyperplasia was present in uteri of children, adolescents, and young adults. METHODS: We studied 19 pediatric/young adult uteri in cases with no clinical history of uterine disease. Random photomicrographs at 100x, taken at 1, 5, and 10 mm beneath the endometrium, were assessed for increased cellularity and nucleus/cell ratio, as compared to normal myometrium in the outer third of the same uterus. RESULTS: Myometrial hyperplasia was generally absent in prepubertal uteri, first appeared in adolescent uteri just beneath the endometrium, and was found at 5 mm depth only after age 18. It decreased with depth beneath the endometrium (P<0.05). CONCLUSIONS: Myometrial hyperplasia is not a congenital anatomic variation in myometrial differentiation, but rather an age-related acquired structural variation. Its relationship to common adolescent symptoms of dysmenorrhea and anovulatory bleeding remains unknown and unexplored.
Stewart F Cramer; Aasim I Padela; Carol E Marchetti; Patricia M Newcomb; Debra S Heller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric and adolescent gynecology     Volume:  16     ISSN:  1083-3188     ISO Abbreviation:  J Pediatr Adolesc Gynecol     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-04     Completed Date:  2004-05-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9610774     Medline TA:  J Pediatr Adolesc Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Department of Pathology, Rochester General Hospital, University of Rochester School of Medicine, Rochester, New York 14621, USA.
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MeSH Terms
Cell Nucleus / pathology
Child, Preschool
Hyperplasia / diagnosis,  physiopathology
Myometrium / pathology*
Uterine Diseases / diagnosis,  pathology*,  physiopathology
Grant Support

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