Document Detail


Myomectomy Decreases Abnormal Uterine Peristalsis and Increases Pregnancy Rate.
MedLine Citation:
PMID:  22070929     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The relationship between fibroids and infertility remains a critical and unresolved question. During the implantation phase, it is known that uterine peristalsis is dramatically reduced, which is thought to facilitate implantation of the embryo to the endometrium. In the previous study, using a cine MRI mode, we found that less than half of the patients with intramural fibroids exhibited abnormal uterine peristalsis during the mid-luteal phase. In the present study, we further investigated whether myomectomy for patients in the high peristalsis group is a constructive method to normalize uterine peristalsis. METHODS: The frequency of junctional zone movement was evaluated using a cine MRI mode during the mid-luteal phase. Fifteen infertility patients, who had intramural myomas and exhibited abnormal uterine peristalsis (≥2 times/3 min) in their first MRI, underwent myomectomy and a second MRI. After receiving the second MRI, patients underwent infertility treatment for at least 8 months, and pregnancy rate was evaluated prospectively. RESULTS: Among 15 patients, the frequency of uterine peristalsis was normalized (0 or 1 time/3min) in 14 patients. Following myomectomy and second MRI test, 6 of the 15 patients achieved pregnancy (n = 15, pregnancy rate: 40%). CONCLUSIONS: The presence of uterine fibroids might induce abnormal uterine peristalsis in some patients, leading to infertility, and myomectomy may improve fertility in these patients.
Authors:
Osamu Yoshino; Osamu Nishii; Yutaka Osuga; Hisanori Asada; Shigeo Okuda; Makoto Orisaka; Masaaki Hori; Toshihiro Fujiwara; Toshihiko Hayashi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-8
Journal Detail:
Title:  Journal of minimally invasive gynecology     Volume:  -     ISSN:  1553-4669     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235322     Medline TA:  J Minim Invasive Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 AAGL. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan; Department of Obstetrics and Gynecology, Mizonokuchi Hospital, Teikyo University, Kanagawa, Japan.
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