| Myomatous erythrocytosis syndrome: further proof for the pathogenic role of erythropoietin. | |
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MedLine Citation:
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PMID: 18663256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Myomatous erythrocytosis syndrome is defined by the combination of erythrocytosis, myomatous uterus and persistent restoration of normal haematological values after hysterectomy. A pathogenic role of erythropoietin is suggested by clinical and experimental data. CASE REPORT: A postmenopausal patient is described with the classical clinical signs of the myomatous erythrocytosis syndrome. During hysterectomy we demonstrated a large gradient between the erythropoietin levels in the uterine vein and artery, providing direct evidence for in vivo erythropoietin production by the myomatous uterus. CONCLUSION: While erythropoietin and its receptor are consecutively expressed in normal and myomatous uterine tissue, it is amazing that erythrocytosis occurs so rarely in such a frequent disorder as uterine myomatous. We strongly advocate cytogenetic examination of the myomatous tissue of subsequent patients with this entity. |
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Authors:
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L T Vlasveld; C W M de Wit; R A Verweij; A Castel; P M Jansen; A A W Peters |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 66 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 283-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Bronovo Hospital, The Hague, the Netherlands. tomvlasveld@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diagnosis, Differential Erythropoietin / blood* Female Follow-Up Studies Humans Immunohistochemistry Leiomyoma / blood, diagnosis* Middle Aged Polycythemia / blood, diagnosis* Syndrome Uterine Neoplasms / blood, diagnosis* |
| Chemical | |
Reg. No./Substance:
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11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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