Document Detail

Myoglobin functions in the heart.
MedLine Citation:
PMID:  24859377     Owner:  NLM     Status:  Publisher    
The physiological role of myoglobin (Mb) within the heart depends on its oxygenation state. The myocardium exhibits a broad oxygen partial pressure (pO2) spectrum with a transmural gradient from the epicardial to the subendocardial layers, ranging from arterial values to an average of 19.3mmHg down to 0mmHg. The function of Mb as an O2 storage is well appreciated, especially during systolic compression. Besides, Mb controls myocardial nitric oxide (NO) homeostasis and thus modulates mitochondrial respiration under physiological and pathological conditions. We recently discovered the role of Mb as a myocardial O2 sensor; in its oxygenated state Mb (oxyMb) scavenges NO, protecting the heart from the deleterious effects of excessive NO. Under hypoxia, however, deoxygenated Mb (deoxyMb) changes its role from an NO scavenger to an NO producer. The NO produced protects the cell from short phases of hypoxia and from myocardial ischemia/reperfusion (I/R) injury. In this review we summarize the traditional and novel aspects of Mb and its (patho)physiological role in the heart.
Ulrike B Hendgen-Cotta; Malte Kelm; Tienush Rassaf
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Publication Detail:
Type:  REVIEW     Date:  2014-5-22
Journal Detail:
Title:  Free radical biology & medicine     Volume:  -     ISSN:  1873-4596     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
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