| Myogenic tone of the rat testicular subcapsular artery has a role in autoregulation of testicular blood supply. | |
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MedLine Citation:
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PMID: 2346776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An in vitro method is described for the isolation, cannulation, and pressurization of a 10-mm segment of the adult rat testicular subcapsular artery by use of a 200-microns micropipette connected to an adjustable-height reservoir. External and internal arterial diameters were measured by a digital filar micrometer eyepiece calibrated with a Microcode scaler. Transmural pressure was increased stepwise by 20 mm Hg from 20 to 180 mm Hg at 10-min intervals. The following novel triphasic myogenic response was found: a 22.5% increase in lumen cross-sectional area from 20 to 40 mm Hg (p less than 0.05); a 37.3% decrease in lumen cross-sectional area from 40 to 100 mm Hg (p less than 0.05); and a 72.4% increase in lumen cross-sectional area from 100 to 180 mm Hg (p less than 0.05). Papaverine (0.1 mM) completely blocked the transmural pressure-induced vasoconstriction, indicating an active increase in vascular smooth muscle tone by transmural pressure. The calculated blood flow through the testicular subcapsular artery of the adult rat, from measured internal radii at various transmural pressures ranging from 20 to 180 mm Hg by Poiseuille's equation, was constant from 40 to 100 mm Hg and showed a progressive increase from 100 to 180 mm Hg. These data suggest that the myogenic response of the adult rat testicular subcapsular artery may have an important role in the autoregulation of the testicular blood supply. |
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Authors:
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J R Davis |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Biology of reproduction Volume: 42 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-07-11 Completed Date: 1990-07-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 727-35 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects, physiology Blood Pressure / physiology Catheterization / methods Culture Techniques / methods Homeostasis / physiology* Male Muscle Tonus Papaverine / pharmacology Rats Rats, Inbred Strains Regional Blood Flow Testis / blood supply* Vasodilation |
| Chemical | |
Reg. No./Substance:
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58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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