Document Detail

Myogenic reactivity is enhanced in rat radial uterine arteries in a model of maternal undernutrition.
MedLine Citation:
PMID:  15295388     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to determine if maternal undernutrition during pregnancy altered myogenic tone in small radial uterine arteries. STUDY DESIGN: Myogenic tone of radial uterine arteries was studied from late pregnant rats (day 20) that were fed either ad libitum or globally restricted diet (moderately severe dietary restriction) throughout pregnancy. RESULTS: Myogenic tone was enhanced in the radial uterine arteries from the diet-restricted compared with the ad libitum group. Nitric oxide synthase inhibition enhanced myogenic tone in the arteries from the ad libitum group only. Prostaglandin H synthase inhibition had no effect on myogenic tone in either group. CONCLUSION: Diet restriction during pregnancy enhances myogenic tone in the radial uterine arteries partly as a result of impairment of the nitric oxide synthase pathway. Enhanced myogenic tone in turn may reduce uteroplacental blood flow and, thus, contribute to reduced birth weight, and lead to effects of fetal programming in utero that can have long-term consequences into adulthood.
Sukrutha Veerareddy; Morag E Campbell; Sarah J Williams; Philip N Baker; Sandra T Davidge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-05     Completed Date:  2004-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  334-9     Citation Subset:  AIM; IM    
Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada.
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MeSH Terms
Cyclooxygenase Inhibitors / pharmacology
Malnutrition / complications,  physiopathology*
Meclofenamic Acid / pharmacology
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide Synthase / antagonists & inhibitors
Placental Circulation / physiology*
Pregnancy Complications / physiopathology*
Rats, Sprague-Dawley
Uterus / blood supply*
Vasodilation / drug effects
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 50903-99-6/NG-Nitroarginine Methyl Ester; 644-62-2/Meclofenamic Acid; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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