Document Detail

Myogenic mechanisms in the kidney.
MedLine Citation:
PMID:  2681599     Owner:  NLM     Status:  MEDLINE    
Myogenic mechanisms in the kidney are part of the autoregulation mechanism which maintains a constant renal blood flow at varying arterial pressure. Concomitant autoregulation of glomerular pressure and filtration indicates regulation of preglomerular resistance. Model and experimental studies were performed to evaluate two mechanisms in the kidney, myogenic response and tubuloglomerular feedback. A mathematical model showed good autoregulation through a myogenic response, aimed at maintaining a constant wall tension in each segment of the preglomerular vessels. Tubuloglomerular feedback gave rather poor autoregulation. The myogenic mechanism showed 'descending' resistance changes, starting in the larger arteries, and successively affecting downstream preglomerular vessels at increasing arterial pressures. This finding was supported by micropuncture measurements of pressure in the terminal interlobular arteries. Evidence that the mechanism was myogenic was obtained by exposing the kidney to a subatmospheric pressure of 40 mmHg; this led to an immediate increase in renal resistance, which could not be prevented by denervation or various blocking agents.
K Aukland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-12-20     Completed Date:  1989-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S71-6; discussion S77     Citation Subset:  IM    
Department of Physiology, University of Bergen, Norway.
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MeSH Terms
Homeostasis / physiology*
Hypertension / physiopathology
Kidney / blood supply,  physiology*
Models, Biological
Muscle, Smooth, Vascular / physiology
Renal Artery / physiology
Renal Circulation / physiology
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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