| Myofilament length dependent activation. | |
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MedLine Citation:
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PMID: 20053351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Frank-Starling law of the heart describes the interrelationship between end-diastolic volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat basis. The main cellular mechanism that underlies this phenomenon is an increase in the responsiveness of cardiac myofilaments to activating Ca(2+) ions at a longer sarcomere length, commonly referred to as myofilament length-dependent activation. This review focuses on what molecular mechanisms may underlie myofilament length dependency. Specifically, the roles of inter-filament spacing, thick and thin filament based regulation, as well as sarcomeric regulatory proteins are discussed. Although the "Frank-Starling law of the heart" constitutes a fundamental cardiac property that has been appreciated for well over a century, it is still not known in muscle how the contractile apparatus transduces the information concerning sarcomere length to modulate ventricular pressure development. |
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Authors:
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Pieter P de Tombe; Ryan D Mateja; Kittipong Tachampa; Younss Ait Mou; Gerrie P Farman; Thomas C Irving |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-01-04 |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 48 ISSN: 1095-8584 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-06-24 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 851-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA. pdetombe@lumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actin Cytoskeleton
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metabolism* Animals Heart / physiology Humans Models, Biological Myocardial Contraction / physiology Sarcomeres / metabolism Troponin I / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL062426-100006/HL/NHLBI NIH HHS; P01-HL62426/HL/NHLBI NIH HHS; R01 HL075494-06/HL/NHLBI NIH HHS; R01 HL075494-08/HL/NHLBI NIH HHS; R01-HL75494/HL/NHLBI NIH HHS; T32 HL007692-20/HL/NHLBI NIH HHS; T32-007692//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Troponin I |
| Comments/Corrections | |
Comment In:
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J Mol Cell Cardiol. 2010 Oct;49(4):707-8; author reply 709
[PMID:
20624395
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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