Document Detail

Myofilament length dependent activation.
MedLine Citation:
PMID:  20053351     Owner:  NLM     Status:  MEDLINE    
The Frank-Starling law of the heart describes the interrelationship between end-diastolic volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat basis. The main cellular mechanism that underlies this phenomenon is an increase in the responsiveness of cardiac myofilaments to activating Ca(2+) ions at a longer sarcomere length, commonly referred to as myofilament length-dependent activation. This review focuses on what molecular mechanisms may underlie myofilament length dependency. Specifically, the roles of inter-filament spacing, thick and thin filament based regulation, as well as sarcomeric regulatory proteins are discussed. Although the "Frank-Starling law of the heart" constitutes a fundamental cardiac property that has been appreciated for well over a century, it is still not known in muscle how the contractile apparatus transduces the information concerning sarcomere length to modulate ventricular pressure development.
Pieter P de Tombe; Ryan D Mateja; Kittipong Tachampa; Younss Ait Mou; Gerrie P Farman; Thomas C Irving
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-01-04
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  48     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-06-24     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  851-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Actin Cytoskeleton / metabolism*
Heart / physiology
Models, Biological
Myocardial Contraction / physiology
Sarcomeres / metabolism
Troponin I / metabolism
Grant Support
P01 HL062426/HL/NHLBI NIH HHS; P01 HL062426-100006/HL/NHLBI NIH HHS; P01-HL62426/HL/NHLBI NIH HHS; P41 GM103622/GM/NIGMS NIH HHS; R01 HL075494/HL/NHLBI NIH HHS; R01 HL075494-06/HL/NHLBI NIH HHS; R01-HL75494/HL/NHLBI NIH HHS; T32 HL007692/HL/NHLBI NIH HHS; T32 HL007692-20/HL/NHLBI NIH HHS; T32-007692//PHS HHS
Reg. No./Substance:
0/Troponin I
Comment In:
J Mol Cell Cardiol. 2010 Oct;49(4):707-8; author reply 709   [PMID:  20624395 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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