Document Detail

Myofibroblasts and local angiotensin II in rat cardiac tissue repair.
MedLine Citation:
PMID:  9076939     Owner:  NLM     Status:  MEDLINE    
Tissue repair is a fundamental property of vascularized tissue. At sites of injury, phenotypically transformed fibroblast-like cells are responsible for fibrous tissue formation, expressed principally as type I and III fibrillar collagens. These cells are termed myofibroblasts because they contain alpha-smooth muscle actin microfilaments and are contractile. In vivo studies of injured rat cardiac tissues and in vitro cell culture studies have shown that such fibroblast-like cells contain requisite components for angiotensin peptide generation and angiotensin II receptors. Such locally generated angiotensin II acts in an autocrine paracrine manner to regulate collagen turnover and thereby tissue homeostasis in injured tissue.
K T Weber; Y Sun; L C Katwa
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  29     ISSN:  1357-2725     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-25     Completed Date:  1997-04-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-42     Citation Subset:  IM    
Department of Internal Medicine, University of Missouri Health Sciences Center, Columbia, USA.
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MeSH Terms
Angiotensin II / metabolism*
Collagen / genetics
Fibroblasts / pathology
Gene Expression
Heart Injuries / metabolism*,  pathology*
Models, Cardiovascular
Wound Healing / genetics,  physiology
Grant Support
R01-31701//PHS HHS
Reg. No./Substance:
11128-99-7/Angiotensin II; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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