Document Detail


Myofibroblasts and local angiotensin II in rat cardiac tissue repair.
MedLine Citation:
PMID:  9076939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue repair is a fundamental property of vascularized tissue. At sites of injury, phenotypically transformed fibroblast-like cells are responsible for fibrous tissue formation, expressed principally as type I and III fibrillar collagens. These cells are termed myofibroblasts because they contain alpha-smooth muscle actin microfilaments and are contractile. In vivo studies of injured rat cardiac tissues and in vitro cell culture studies have shown that such fibroblast-like cells contain requisite components for angiotensin peptide generation and angiotensin II receptors. Such locally generated angiotensin II acts in an autocrine paracrine manner to regulate collagen turnover and thereby tissue homeostasis in injured tissue.
Authors:
K T Weber; Y Sun; L C Katwa
Related Documents :
9804259 - The phagocytic activity of human first trimester extravillous trophoblast.
18585779 - Nanofibrous polyhydroxyalkanoate matrices as cell growth supporting materials.
7949369 - Transient expression of type ii collagen and tissue mobilization during development of ...
18973549 - Characteristic changes of periodontal ligament-derived cells during passage.
22768909 - Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inn...
20507709 - Effect of thermal degradation of sff-based plga scaffolds fabricated using a multi-head...
20095849 - Amifostine metabolite wr-1065 disrupts homologous recombination in mammalian cells.
19856159 - Spermatogenesis and cycle of the seminiferous epithelium.
401499 - Bacillus subtilis ribonucleic acid polymerase mutants conditionally temperature sensiti...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  29     ISSN:  1357-2725     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-25     Completed Date:  1997-04-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-42     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Missouri Health Sciences Center, Columbia, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensin II / metabolism*
Animals
Collagen / genetics
Fibroblasts / pathology
Gene Expression
Heart Injuries / metabolism*,  pathology*
Models, Cardiovascular
Rats
Wound Healing / genetics,  physiology
Grant Support
ID/Acronym/Agency:
R01-31701//PHS HHS
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury.
Next Document:  Tissue inhibitors of metalloproteinases in liver fibrosis.