| Myofibroblastoma of the breast with diverse differentiations. | |
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MedLine Citation:
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PMID: 9199625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The histogenesis of myofibroblastoma of the breast remains unknown. DESIGN: Two cases of myofibroblastoma of the female breast were analyzed using light microscopy and immunohistochemistry. RESULTS: The tumors were well circumscribed and predominantly composed of bland bipolar spindle cells and interspersed bands of hyalinized collagen. Additionally, one tumor contained a cartilaginous island, and the other contained a well-defined small nodule that consisted of fascicular arrangements of mitotically inactive atypical cells, simulating atypical leiomyoma. Both lesions contained a fatty element. Immunohistochemically, spindle tumor cells expressed desmin, alpha-smooth muscle actin, muscle actin, and CD34. The atypical cells were strongly and diffusely positive for all these markers. Both tumors were DNA diploid and had a moderate S-phase fraction. The patients have no evidence of disease 4 and 18 months after simple excision. CONCLUSIONS: Myofibroblastoma of the breast may be a benign mesenchymal neoplasm capable of diverse lines of differentiation. |
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Authors:
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M Fukunaga; S Ushigome |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 121 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-03 Completed Date: 1997-07-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 599-603 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Jikei University School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD34 / analysis Breast Neoplasms / genetics, pathology*, surgery Cell Nucleus / pathology Cell Transformation, Neoplastic Cytoplasm / pathology DNA, Neoplasm / analysis Desmin / analysis Diploidy Female Humans Immunohistochemistry Middle Aged Neoplasms, Muscle Tissue / genetics, pathology*, surgery S Phase S100 Proteins / analysis Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34; 0/DNA, Neoplasm; 0/Desmin; 0/S100 Proteins; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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