Document Detail

Myofibroblastoma: Report of a rare entity in the pediatric population.
MedLine Citation:
PMID:  22901100     Owner:  NLM     Status:  Publisher    
Abstract Fibroblastic and myofibroblastic tumours constitute an important group of neoplasms in children and adolescents. These span the full spectrum of clinical behaviour ranging from benign, to intermediate and malignant. We report a case of a benign mesenchymal tumour with myofibroblastic differentiation in a 9-year-old girl arising in the left groin which met the histologic features described for myofibroblastoma in adults. Two types are recognized in adults, namely angiomyofibroblastoma and mammary-type myofibroblastoma of soft tissue. Our case shared features of both these subtypes but was not typical of either one, and we therefore designated our case simply as 'myofibroblastoma'. Our case showed expression of estrogen receptor protein characteristic of adult lesions but not a deletion of 13q14 as has been reported in some adult cases. In a review of the English literature, only six cases have been reported in patients under 21 and all were teenagers except one. Pediatric surgeons, oncologists and pathologists should be aware that such a benign entity can occur in this patient population and could be confused with other lesions including malignant ones.
Rose Chami; Kjetil Ertresvaag; Georges Azzie; Paul Scott Thorner
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-17
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Hospital for Sick Children, Pediatric Laboratory Medicine.
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