Document Detail

Myocytes' apoptosis and proliferation in endomyocardial biopsy as prognostic factors in terminal heart failure.
MedLine Citation:
PMID:  11678324     Owner:  NLM     Status:  MEDLINE    
The aim of the preliminary study was to evaluate the role of apoptosis and proliferation of myocytes in order to predict the prognosis and optimal treatment of patients with end-stage dilated cardiomyopathy. Endomyocardial biopsy was performed during open-heart surgery (reductive annuloplasty of double orifice) in 19 patients with end-stage dilated cardiomyopathy. The terminal deoxynucleotidyl transferase d-UTP-biotin nick-end labelling (TUNEL) method was used for the detection of apoptosis, and immunohistochemical methods were used for the evaluation of inhibitor of apoptosis such as proto-oncogene Bcl-2 (B-cell lymphoma gene), and proliferative markers such as proliferation cell nuclear antigen (PCNA) and Ki-67 proliferative antigen. The increased percentage of apoptotic myocytes and decreased expression of bcl-2 is associated with earlier death after surgery. Increased expression of proliferation markers of myocytes in patients who survived seven years after surgery compared to those who died within three years suggest that adult cardiomyocytes are not terminally differentiated and this might represent potential growth reserve of the diseased heart. Based on our preliminary study we may conclude that myocytes' apoptosis and proliferative activity might help us to predict the prognosis and optimal treatment of patients with end-stage dilated cardiomyopathy.
M Zorc; O V Porenta; R Pleskovic; N Radovanović; A Cijan; A Milosavijević; D Petrovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  442     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2001  
Date Detail:
Created Date:  2001-10-25     Completed Date:  2002-03-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  R163-4     Citation Subset:  IM    
Institute of Histology and Embryology, Medical Faculty, Ljubljana, Slovenia.
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MeSH Terms
Cardiomyopathy, Dilated / pathology*
Cell Division
In Situ Nick-End Labeling
Middle Aged
Muscle Fibers, Skeletal / chemistry,  pathology*
Myocardium / pathology*
Predictive Value of Tests
Proliferating Cell Nuclear Antigen / analysis
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen

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