Document Detail


Myocyte replacement therapy: skeletal myoblasts.
MedLine Citation:
PMID:  18293896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skeletal myoblasts function as precursors to adult skeletal myocytes. More so than other muscle progenitors, their capacity for de novo self-renewal and their positive functional effects in the cardiac environment have been demonstrated, even though they do not attain a cardiomyocyte phenotype. Autologous skeletal myoblasts are easily procured by established methods and can be administered into diseased myocardium safely and without technical difficulty, features that at this time set them apart from any other myogenic cell. Clinical studies in patients with chronic myocardial disease have consistently reported modest improvements in ventricular function and clinical status. Data from the Myogenesis Heart efficiency and Regeneration Trial (MYOHEART) trial are currently being evaluated. Larger, randomized, placebo-controlled studies in patients with congestive heart failure due to postinfarction systolic left ventricular dysfunction are under way, such as Myoblast Autologous Grafting in Ischemic Cardiomayopathy (MAGIC) and Multicenter Study of the Safety and Cardiovascular Effects Of Myoblasts in Congestive Heart Failure (MARVEL). The future role of skeletal myoblasts in the clinical setting will be determined by the results of randomized trials as well as by the investigation of subsequent generations of myoblasts, engineered for enhanced efficacy.
Authors:
Warren Sherman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell transplantation     Volume:  16     ISSN:  0963-6897     ISO Abbreviation:  Cell Transplant     Publication Date:  2007  
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  971-5     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY, USA. ws2157@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Catheterization / methods
Cell Transplantation / methods*
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Heart Failure / therapy
Humans
Multicenter Studies as Topic
Myoblasts, Skeletal / transplantation*
Myocardial Ischemia / therapy
Randomized Controlled Trials as Topic
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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