Document Detail


Myocyte changes in heart failure.
MedLine Citation:
PMID:  22108722     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Structural remodeling is a major feature of heart failure and typically precedes the development of symptomatic disease. Structural remodeling of the heart reflects changes in myocyte morphology. Disproportional myocyte growth is observed in pathologic concentric hypertrophy (myocyte thickening) and in eccentric dilated hypertrophy (myocyte lengthening). Alterations in myocyte shape lead to changes in chamber geometry and wall stress. Human and animal studies indicate that changes in myocyte morphology are reversible. Normalization or reversal of maladaptive cardiomyocyte remodeling should be a therapeutic aim that can prevent deterioration or improve cardiac function in heart failure.
Authors:
Olga V Savinova; A Martin Gerdes
Publication Detail:
Type:  Journal Article     Date:  2011-10-13
Journal Detail:
Title:  Heart failure clinics     Volume:  8     ISSN:  1551-7136     ISO Abbreviation:  Heart Fail Clin     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231934     Medline TA:  Heart Fail Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Cardiovascular Health Research Center, Sanford Research, University of South Dakota, 2301 East 60th Street North, Sioux Falls, SD 57104, USA.
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