Document Detail


Myocyte cell loss and myocyte hypertrophy in the aging rat heart.
MedLine Citation:
PMID:  2946746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the effects of age on the myocardium, the functional and structural characteristics of the heart were studied in rats at 3, 10 to 12 and 19 to 21 months of age. Systemic arterial pressure, left ventricular pressure and its first derivative (dP/dt) and heart rate were comparable in the three animal groups. In the interval between 3 and 10 to 12 months, mean myocyte cell volume per nucleus increased 53 and 26% in the left and the right ventricle, respectively. The total number of myocyte nuclei remained constant in either ventricle. In the following period, between 10 to 12 and 19 to 21 months, a 39% further cellular hypertrophy on the left side of the heart was found in association with an 18% loss of cells in the ventricle. Cell loss was accompanied by discrete areas of interstitial and replacement fibrosis in the subendocardium. In contrast, no myocardial damage was observed in the right ventricle, and the measured 35% additional enlargement of myocytes occurred without a change in cell number. Thus, the aging left ventricle is composed of a smaller number of hypertrophied cells. Cellular hypertrophy may explain the unaltered cardiac function of the aged myocardium.
Authors:
P Anversa; B Hiler; R Ricci; G Guideri; G Olivetti
Related Documents :
2149616 - Effects of captopril on the hypertrophied heart of essential hypertensive patients.
526216 - Systolic time intervals and other cardiovascular changes following leg elevation.
10806986 - Pulmonary venous flow and mitral inflow velocity pattern in uncomplicated obesity: evid...
1348916 - The antihypertensive and cardiac hemodynamic effects of nebivolol.
8238566 - Renin-angiotensin system and minoxidil-induced cardiac hypertrophy in rats.
18082886 - Meta-analysis of 24-hour intraocular pressure studies evaluating the efficacy of glauco...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  8     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-01-05     Completed Date:  1987-01-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1441-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Cardiomegaly / pathology*
Cell Count
Cell Nucleus / ultrastructure
Male
Myocardium / pathology*,  ultrastructure
Organ Size
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
HL-24479/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Percutaneous coronary laser thermal angioplasty.
Next Document:  The pathogenesis and prevention of aortocoronary vein bypass graft occlusion and restenosis after ar...