| Myoclonic activity associated with cefmetazole, with a review of neurotoxicity of cephalosporins. | |
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MedLine Citation:
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PMID: 3233864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reported a case of a 66-year-old female with uremia who developed myoclonic activity after administration of cefmetazole (4g/2 days). Curiously, the level of the antibiotics (236 micrograms/ml) in the cerebrospinal fluid (CSF) was higher than that in the blood (103 micrograms/ml). Myoclonic activity faded away after cessation of the antibiotics. This is the first case reported developing neurotoxicity associated with intravenous administration of cefmetazole. In addition, the curious pharmacokinetic dynamics of cephalosporin in uremia is discussed. |
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Authors:
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T Uchihara; H Tsukagoshi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 90 ISSN: 0303-8467 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 1988 |
Date Detail:
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Created Date: 1989-05-11 Completed Date: 1989-05-11 Revised Date: 2009-10-14 |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: ITALY |
Other Details:
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Languages: eng Pagination: 369-71 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Asahi General Hospital, Chiba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cefmetazole / administration & dosage, adverse effects* Cephalosporins / adverse effects*, cerebrospinal fluid Female Humans Infusions, Parenteral Myoclonus / chemically induced* Uremia / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 56796-20-4/Cefmetazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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