Document Detail

Myoclonic activity associated with cefmetazole, with a review of neurotoxicity of cephalosporins.
MedLine Citation:
PMID:  3233864     Owner:  NLM     Status:  MEDLINE    
We reported a case of a 66-year-old female with uremia who developed myoclonic activity after administration of cefmetazole (4g/2 days). Curiously, the level of the antibiotics (236 micrograms/ml) in the cerebrospinal fluid (CSF) was higher than that in the blood (103 micrograms/ml). Myoclonic activity faded away after cessation of the antibiotics. This is the first case reported developing neurotoxicity associated with intravenous administration of cefmetazole. In addition, the curious pharmacokinetic dynamics of cephalosporin in uremia is discussed.
T Uchihara; H Tsukagoshi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  90     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  369-71     Citation Subset:  IM    
Department of Internal Medicine, Asahi General Hospital, Chiba, Japan.
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MeSH Terms
Cefmetazole / administration & dosage,  adverse effects*
Cephalosporins / adverse effects*,  cerebrospinal fluid
Infusions, Parenteral
Myoclonus / chemically induced*
Uremia / cerebrospinal fluid
Reg. No./Substance:
0/Cephalosporins; 56796-20-4/Cefmetazole

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