Document Detail

Myocarditis and ARVC/D: variants or mimics?
MedLine Citation:
PMID:  23773988     Owner:  NLM     Status:  Publisher    
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a disease characterized by fibro-fatty replacement of the right ventricular myocardium, generally considered to be based upon variations in desmosomal genes. However, its pathogenesis is not completely clear since myocarditis and high intensity athletics have both been postulated to contribute to the onset and progression of the disease pattern. We observed a 21-year-old female who presented with fulminant lymphocytic myocarditis, and subsequently fulfilled the diagnostic criteria for ARVC/D by imaging and electrocardiographic characteristics after complete resolution of left ventricular abnormalities associated with myocarditis. Genetic study was however negative for common mutations associated with ARVC/D. Programmed electrical stimulation revealed easily inducible ventricular tachycardia originating from the right ventricular apex, and she received an implantable cardioverter defibrillator. This report supports the hypothesis of a common pathophysiology of ARVC/D associated with desmosomal dysfunction, which can be based upon genetic predisposition or acquired injury.
Tanyanan Tanawuttiwat; Solomon J Sager; Joshua M Hare; Robert J Myerburg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-14
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  -     ISSN:  1556-3871     ISO Abbreviation:  Heart Rhythm     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Inc.
Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, USA.
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