Document Detail

Myocarditis of mixed connective tissue disease: favourable outcome after intravenous pulsed cyclophosphamide.
MedLine Citation:
PMID:  10088961     Owner:  NLM     Status:  MEDLINE    
A 30-year-old woman with mixed connective tissue disease was admitted with Wernicke's aphasia and progressive dyspnoea with chest pain. Multiple brain infarcts on a computed tomographic scan were compatible with a thromboembolic aetiology. Echocardiography showed marked hypokinesia of the posterior wall, biventricular dilatation and a decreased left-ventricle ejection fraction (40%). A diagnosis of myocarditis was made on myocardial biopsies disclosing interstitial lymphocytic infiltrates and myocardial fibre necrosis. A treatment with steroids and monthly pulsed cyclophosphamide was introduced. The heart function rapidly improved as assessed by a left-ventricle ejection fraction of 55% and remained stable 17 months thereafter.
C Hammann; C Y Genton; A Delabays; A Bischoff Delaloye; J Bogousslavsky; F Spertini
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  18     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  1999  
Date Detail:
Created Date:  1999-05-04     Completed Date:  1999-05-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  85-7     Citation Subset:  IM    
Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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MeSH Terms
Cyclophosphamide / administration & dosage*
Diagnosis, Differential
Echocardiography, Doppler
Follow-Up Studies
Heart Ventricles / pathology,  physiopathology,  ultrasonography
Immunosuppressive Agents / administration & dosage*
Injections, Intravenous
Mixed Connective Tissue Disease / complications*,  diagnosis,  drug therapy
Myocarditis / diagnosis,  drug therapy,  etiology*
Stroke Volume
Tomography, X-Ray Computed
Reg. No./Substance:
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide

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