Document Detail


Myocarditis in children.
MedLine Citation:
PMID:  20869648     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Myocarditis is an inflammatory disease of the cardiac muscle caused by myocardial infiltration of immunocompetent cells following any kind of cardiac injury. Acute myocarditis in childhood is often a result of a viral infection that produces myocardial necrosis and triggers an immune response to eliminate the infectious agent. Chronic myocardial injury may develop by postinfectious immune or autoimmune processes or be associated with systemic autoimmune diseases, which, in the long run, are responsible for persistent or progressive ventricular dysfunction, arrhythmias, and cardiac complaints. The disease often presents as an acute form of dilated cardiomyopathy, but because of its broad spectrum of presentation the clinical diagnosis is frequently misleading. If the underlying infectious or immune-mediated causes of the disease are carefully defined by clinical and biopsy-based tools, specific immunosuppressive and antiviral treatment options in addition to basic symptomatic therapy may avoid unnecessary interventions and improve prognosis in many patients with acute and chronic disease.
Authors:
Uwe Kühl; Heinz-Peter Schultheiss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart failure clinics     Volume:  6     ISSN:  1551-7136     ISO Abbreviation:  Heart Fail Clin     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231934     Medline TA:  Heart Fail Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  483-96, viii-ix     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cardiology and Pneumology, University Medicine Berlin, Campus Benjamin-Franklin, Medical Clinic II, Hindenburgdamm 30, Berlin 1210, Germany. uwe.kuehl@charite.de
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