Document Detail

Myocardial and vascular dysfunction in systemic sclerosis: the potential role of noninvasive assessment in asymptomatic patients.
MedLine Citation:
PMID:  17156866     Owner:  NLM     Status:  MEDLINE    
Systemic sclerosis (SSc) is a multi-system disorder characterized by widespread vascular lesions and fibrosis of skin and distinct internal organs. The aim of the present study was to analyze possible associations of left ventricular (LV) myocardial function with coronary flow reserve (CFR) and endothelial function in asymptomatic patients with SSc. Thirty healthy subjects and 33 age- and sex-comparable asymptomatic SSc patients underwent standard Doppler Myocardial Imaging, Strain Rate (SR) Imaging of interventricular septum (IVS) and LV lateral wall, transthoracic CFR of left anterior descending coronary vessel, and brachial artery vasodilatation measurement. In SSc patients, LV myocardial early diastolic peak velocity, peak systolic SR and strain were both reduced in basal and middle IVS, and in basal and middle LV lateral wall (p<0.001). In addition, both CFR (p<0.0001) and endothelial flow-mediated dilatation (p<0.001) were significantly lower in SSc patients. By stepwise forward multivariate analyses, CFR (p<0.001) and endothelial function (p<0.001) were powerful independent determinants of middle LV strain of SSc patients. In conclusion, SR Imaging, transthoracic CFR and brachial artery flow-mediated dilatation are valuable non-invasive and easy-repeatable tools for detecting early LV myocardial and vascular involvement caused by SSc.
Antonello D'Andrea; Pio Caso; Sergio Cuomo; Fortunato Scotto di Uccio; Raffaella Scarafile; Gemma Salerno; Silvio Romano; Stefano Stisi; Marino Scherillo; Raffaele Calabrò
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Publication Detail:
Type:  Letter     Date:  2006-12-05
Journal Detail:
Title:  International journal of cardiology     Volume:  121     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  298-301     Citation Subset:  IM    
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MeSH Terms
Blood Flow Velocity
Blood Pressure
Coronary Circulation
Echocardiography, Doppler
Endothelium, Vascular / physiopathology*,  ultrasonography
Heart Ventricles / physiopathology,  ultrasonography
Multivariate Analysis
Scleroderma, Systemic / complications,  physiopathology*
Stroke Volume
Ventricular Dysfunction, Left / complications,  physiopathology*,  ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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