| Myocardial ultrasonic tissue characterization for estimating histological abnormalities in hypertrophic cardiomyopathy: comparison with endomyocardial biopsy findings. | |
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MedLine Citation:
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PMID: 11701936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: In this study, we investigated the clinical usefulness of ultrasonic tissue characterization with integrated backscatter for the evaluation of myocardial histological abnormalities in comparison with endomyocardial biopsy findings in patients with hypertrophic cardiomyopathy. METHODS: Twenty patients with hypertrophic cardiomyopathy and 20 normal subjects were enrolled in this study. We measured two parameters for the ultrasonic tissue characterization with integrated backscatter: the magnitude of the cardiac-cycle-dependent variation in integrated backscatter signals (cdv-IB) and the mean value of integrated backscatter signals calibrated by the pericardium (cal-IB). These parameters were measured at both the interventricular septum and the left ventricular posterior wall. Histological findings of right ventricular endomyocardial biopsy specimens were analyzed by computer image analyzer. RESULTS: cdv-IB was significantly lower and cal-IB significantly higher in both the interventricular septum and the left ventricular posterior wall in patients with hypertrophic cardiomyopathy compared with normal subjects. In patients with hypertrophic cardiomyopathy, the degree of myocardial disarray, interstitial fibrosis, and nonhomogeneity of myocyte size showed positive correlations with cal-IB and negative correlations with cdv-IB. CONCLUSIONS: Ultrasonic tissue characterization with IB enables the noninvasive evaluation of myocardial histological abnormalities in patients with hypertrophic cardiomyopathy. |
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Authors:
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R Mizuno; S Fujimoto; K Yamaji; C Yutani; T Hashimoto; S Nakamura |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Cardiology Volume: 96 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 2001 |
Date Detail:
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Created Date: 2001-11-09 Completed Date: 2002-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 16-23 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel |
Affiliation:
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First Department of Internal Medicine, Nara Medical University, Nara, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy Cardiomyopathy, Hypertrophic / pathology, ultrasonography* Cardiovascular Abnormalities / pathology, ultrasonography* Echocardiography Female Heart Septum / cytology, pathology, ultrasonography Heart Ventricles / cytology, pathology, ultrasonography Humans Male Middle Aged Myocardium / cytology, pathology, ultrastructure* Reproducibility of Results |
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