Document Detail


Myocardial triglycerides increased by fasting. Effects of hypoxia on contractility and enzymatic release.
MedLine Citation:
PMID:  7268216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of fasting on the mechanics of contraction was studied in the isolated perfused rat heart, in oxygenated and hypoxic conditions. Animals were subjected to 48 h of fasting, a condition which produces augmented endogenous triglycerides (TG). Normal and fasted rats were submitted to a 10-min period of hypoxia, which depressed peak tension (Tp), maximal rate of contraction (Tc), and relaxation (Tr); all three parameters recovered with reoxygenation. However, Tp and Tc of hearts of fasted animals were less affected by hypoxia, and Tp, Tc, and Tr attained higher levels during reoxygenation compared with hearts of normally fed animals. These results suggest that as triglycerides are augmented, they might have a beneficial action on the hypoxic heart, though other unknown effects of fasting cannot be discarded. LDH was the only cardiac enzyme whose release in the perfusion medium significantly increased in hypoxic hearts, irrespective of the fasting state of the animal. The positive correlation between LDH and an index of relative recovery (IH) for Tp, Tc, and Tr, indicate that not only hypoxia but a good recovery are necessary to yield high LDH values.
Authors:
E C Lascano; J A Negroni; J R Depaoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  179     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1981  
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / enzymology*
Aspartate Aminotransferases / metabolism
Creatine Kinase / metabolism
Fasting*
Isoenzymes
L-Lactate Dehydrogenase / metabolism
Myocardial Contraction*
Myocardium / enzymology*
Rats
Triglycerides / metabolism*
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Triglycerides; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.7.3.2/Creatine Kinase

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