| Myocardial technetium-99m sestamibi single-photon emission tomography as a prognostic tool in coronary artery disease: multivariate analysis in a long-term prospective study. | |
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MedLine Citation:
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PMID: 7588939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To date several studies have evaluated the accuracy of thallium-201 myocardial scan in risk stratification of coronary artery disease (CAD), while reports using technetium-99m methoxyisobutylisonitrile (MIBI), a tracer particularly suited to single-photon emission tomographic (SPET) imaging, are lacking. To rectify this omission, a prospective study was started in 1988 and at present 176 consecutive, and thus unselected, patients have been enrolled. All of them have been submitted to stress-rest MIBI SPET for the diagnosis or evaluation of CAD; 147 patients (121 males and 26 females, aged 53 +/- 9 years) have completed a surveillance period of at least 36 months following the scintigraphic study (range 36-60 months, mean 43). Sixty-one patients had a documented previous myocardial infarction. The mean pre-test likelihood of CAD was 44% in the patients without prior infarction. The main anamnestic, clinical, EKG and scintigraphic findings were evaluated and statistically correlated with the incidence of ensuing cardiac events using both univariate (chi-square test) and multivariate analysis (logistic regression model). Twenty-nine patients suffered from a cardiac event during the follow-up period (i.e. three cardiac deaths, six myocardial infarctions and 20 cases of unstable angina). Statistical multivariate analysis identified MIBI scan as the only highly significant and independent prognostic predictor [P = 0.006, relative risk (RR) = 17.62]. In detail, the most important scintigraphic parameters were the presence of a reversible defect (P = 0.0089, RR = 5.11) and the extension of the stress perfusion defect (P = 0.0255, RR = 3.27). The presence of typical angina proved to be a slightly significant predictor (P = 0.051, RR = 2.45), while no other examined parameter showed a significant correlation with a bad prognosis.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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P Zanco; A Zampiero; A Favero; N Borsato; F Chierichetti; D Rubello; B Saitta; G Ferlin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 22 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-12-28 Completed Date: 1995-12-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1023-8 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Ospedale S. Giacomo Apostolo, Castelfranco Veneto, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angina, Unstable
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epidemiology Chi-Square Distribution Coronary Disease / epidemiology*, radionuclide imaging* Female Follow-Up Studies Heart / radionuclide imaging* Humans Logistic Models Male Middle Aged Myocardial Infarction / epidemiology Prognosis Prospective Studies Risk Factors Technetium Tc 99m Sestamibi / diagnostic use* Time Factors Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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