Document Detail

Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure.
MedLine Citation:
PMID:  21777743     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: This study sought to determine the potential pathophysiological link between anemia and disease severity, and adverse outcome in heart failure (HF).
BACKGROUND: Anemia frequently accompanies advanced HF; however, the pathophysiological mechanism responsible for the association between anemia and more severe HF remains uncertain. We hypothesized that a depletion of myocardial iron content may provide the biological link.
METHODS: Complementary clinical and basic studies were performed. Hemodynamic, biochemical, and echocardiographic investigations were performed in 9 healthy controls and 25 patients with advanced HF (left ventricular ejection fraction: 23 ± 10%). Tissue iron content and type 1 transferrin receptor (Tfr1) expression were assessed in human myocardial tissue, and the regulation of Tfr1 expression was studied in isolated cardiomyocytes.
RESULTS: HF patients displayed evidence of iron deficiency as measured by lower serum iron (p < 0.05) and transferrin saturation (TFS) (p < 0.05). When subclassified according to the presence of anemia, TFS was lower in anemic compared with nonanemic HF patients, whereas TFS in nonanemic HF patients was intermediate. In association, myocardial iron content was reduced in HF versus non-HF samples (0.49 ± 0.07 μg/g vs. 0.58 ± 0.09 μg/g, p < 0.05), and there was a significant reduction (p < 0.05) in the myocardial mRNA expression of Tfr1, which plays a key role in cellular iron transport. In the context of HF, catecholamines and aldosterone both down-regulated Tfr1 expression in isolated cardiomyocytes.
CONCLUSIONS: This study suggests the presence of iron depletion in the failing human heart, providing a potential link for the association between anemia and adverse prognosis in HF.
Micha T Maeder; Ouda Khammy; Cris Dos Remedios; David M Kaye
Related Documents :
11471653 - Contribution of cardiac muscle cell disorganization to the clinical features of hypertr...
3843593 - Noninvasive tissue characterization of myocardium by topical 1h-and 31p-nuclear magneti...
16750683 - Fractional flow reserve of infarct-related arteries identifies reversible defects on no...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  58     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  474-80     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Heart Failure Research Group, Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Heart Centre, Alfred Hospital, Melbourne, Australia; Cardiology Division, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after p...
Next Document:  Long-term effectiveness of cardiac resynchronization therapy in heart failure patients with unfavora...