Document Detail

Myocardial supply-demand ratio in aortic regurgitation.
MedLine Citation:
PMID:  446174     Owner:  NLM     Status:  MEDLINE    
To analyze the relationship between the myocardial supply and demand for oxygen in patients with aortic regurgitation, the ratio of the diastolic pressure-time index (DPTI) over the systolic pressure-time index (SPTI) was derived from recordings of pressure during cardiac catheterization in 24 patients with aortic regurgitation, and this ratio was compared with that in 14 normal subjects and in ten patients with congestive cardiomyopathy (an ejection fraction less than 0.30). Patients with aortic regurgitation had a DPTI/SPTI of 0.75 +/- 0.06 (mean +/- SE), which was lower than in the normal subjects (1.24 +/- 0.06) and patients with cardiomyopathy (1.06 +/- 0.03) (P less than 0.001). Among the patients with aortic regurgitation, the 13 with a DPTI/SPTI below 0.70 had more severe aortic regurgitation than the 11 with a DPTI/SPTI above 0.70. Aortic regurgitation results in a reduced myocardial supply-demand ratio, as measured by the DPTI/SPTI, which is related to the severity of the valvular regurgitation and is not present in patients with left ventricular dysfunction secondary to congestive cardiomyopathy.
R A Oliveros; C A Boucher; B M Groves; G S Uhl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  76     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Valve Insufficiency / metabolism*
Blood Pressure
Cardiac Output
Cardiomyopathies / metabolism
Heart Catheterization
Heart Rate
Middle Aged
Myocardial Contraction
Myocardium / metabolism*
Oxygen Consumption*
Pulmonary Circulation
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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