Document Detail

Myocardial substrate utilization in anaphylactic shock.
MedLine Citation:
PMID:  2930     Owner:  NLM     Status:  MEDLINE    
Changes in myocardial substrate utilization were studied in anesthetized dogs following the production of anaphylactic shock. Mean arterial blood pressure, cardiac output, and pH decreased significantly during this form of shock. Myocardial FFA oxidation was greatly diminished especially within the first hour following challenge and lactate uptake more than doubled during the same time. Thus, it is concluded that myocardial substrate utilization shifted away from FFA and towards lactate during anaphylactic shock and these changes resembled those observed following an acute, severe hemorrhage, or the administration of E. coli endotoxin.
J J Spitzer
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  151     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-04-09     Completed Date:  1976-04-09     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  28-31     Citation Subset:  IM    
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MeSH Terms
Anaphylaxis / metabolism*,  physiopathology
Blood Pressure
Carbon Dioxide / metabolism
Cardiac Output
Energy Metabolism
Fatty Acids, Nonesterified / metabolism
Heart Rate
Hydrogen-Ion Concentration
Lactates / metabolism
Myocardium / metabolism*
Oxygen Consumption
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lactates; 124-38-9/Carbon Dioxide

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