Document Detail

Myocardial subcellular fractionation studies on cardiomyopathic Syrian hamsters.
MedLine Citation:
PMID:  476746     Owner:  NLM     Status:  MEDLINE    
Myocardial homogenates from control animals and from hamsters with hereditary cardiomyopathy were subjected to analytical subcellular fractionation and enzymic microanalysis. Animals without ventricular hypertrophy or overt heart failure were used in this study. The principal subcellular organelles were characterised by density gradient centrifugation. Apart from evidence of enhanced lysosomal and peroxisomal fragility, probably secondary to the intracellular oedema, the intracellular organelles investigated in this study were unaffected by the myopathic process. Highly significant increases in 5'-nucleotidase activity, a marker for the sarcolemma, and an increased equilibrium density of this organelle were found in the myopathic tissue. Ultrastructural studies revealed patchy myocytolysis associated with lysosomes and with more extensive invaginations of the sarcolemma. It is suggested that a primary defect in membrane composition, leading to increased cation permeability, is the underlying abnormality in the myopathic hamster.
D H Fitchett; J Scott; H R Stephens; T J Peters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  13     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  260-8     Citation Subset:  IM    
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MeSH Terms
Cardiomyopathies / enzymology*,  metabolism,  pathology
Microscopy, Electron
Muscle Proteins / analysis
Myocardium / analysis,  enzymology*,  pathology,  ultrastructure
Nucleotidases / metabolism
Sarcolemma / enzymology
Subcellular Fractions / enzymology
Reg. No./Substance:
0/Muscle Proteins; EC 3.1.3.-/Nucleotidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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