Document Detail

Myocardial strain and strain rate in Kawasaki disease.
MedLine Citation:
PMID:  23515218     Owner:  NLM     Status:  Publisher    
AIMS: We sought to determine whether velocity vector imaging (VVI)-derived left ventricular (LV) myocardial deformation indices could detect subtle myocardial abnormalities in acute Kawasaki disease (KD). METHODS AND RESULTS: The study cohort of children with KD was divided by coronary artery dilation (CAD, Z-score >2.5) and/or uncomplicated vs. treatment-resistant (persistent/recrudescent fever) cases and compared with age-matched controls. Peak systolic LV myocardial strain (ε) and strain rate (SR) were obtained using VVI on pre-treatment echocardiograms. Comparisons were made between controls and (i) the entire KD group, (ii) KD group subdivided by CAD, and (iii) KD group subdivided by treatment resistance. The KD group consisted of 32 children (66% male, 24 ± 20 months). Of these, 17 had CAD and 14 had resistant KD. The control group consisted of 22 children (55% male, 20 ± 17 months). Routine echo indices of LV systolic function were normal for both groups. Compared with controls, KD patients had lower global longitudinal ε (-15.29 vs. -12.94, P = 0.04) and SR (-1.12 vs. -0.87, P = 0.003). On subgroup analysis compared with controls, KD patients with CAD (n = 17) had lower longitudinal ε (-15.29 vs. -11.87, P = 0.02) and SR (-1.12 vs. -0.86, P = 0.005). Subdivided by treatment resistance, compared with controls, those with resistant KD had lower longitudinal ε (-15.29 vs. -11.8, P = 0.01) and SR (-1.12 vs. -0.82, P = 0.003). CONCLUSION: Despite normal LV systolic function by routine echocardiographic measurements, KD patients have reduced longitudinal LV ε and SR, which may be more sensitive indicators of myocardial inflammation and may provide supportive criteria to avoid delayed diagnosis of KD.
Rachel T McCandless; L Luann Minich; Stephen E Wilkinson; Molly L McFadden; Lloyd Y Tani; Shaji C Menon
Related Documents :
10627858 - Psychology in coronary care.
24469738 - Myocardial perfusion mri shows impaired perfusion of the mouse hypertrophic left ventri...
10247478 - Activity of antibiotic admixtures subjected to different freeze-thaw treatments.
23800548 - Cardiac steatosis and left ventricular hypertrophy in patients with generalized lipodys...
3019608 - Dilated cardiomyopathy: emerging role of endomyocardial biopsy.
9200538 - High-performance liquid chromatographic determination of myocardial interstitial dihydr...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-20
Journal Detail:
Title:  European heart journal cardiovascular Imaging     Volume:  -     ISSN:  2047-2412     ISO Abbreviation:  Eur Heart J Cardiovasc Imaging     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101573788     Medline TA:  Eur Heart J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Cardiology, Department of Pediatrics, Primary Children's Medical Center and the University of Utah, 100 N. Mario Capecchi Drive, Salt Lake City, UT, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Accounting for Costs, QALYs, and Capacity Constraints: Using Discrete-Event Simulation to Evaluate A...
Next Document:  Effects of subacute dietary salt intake and acute volume expansion on diastolic function in young no...