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Myocardial scar identification based on analysis of Look-Locker and 3D late gadolinium enhanced MRI.
MedLine Citation:
PMID:  24643328     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study is to introduce and evaluate an approach for objective and reproducible scar identification from late gadolinium enhanced (LGE) MR by analysis of LGE data with post-contrast T1 mapping from a routinely acquired T1 scout Look-Locker (LL) sequence. In 90 post-infarction patients, a LL sequence was acquired prior to a three-dimensional LGE sequence covering the entire left ventricle. In 60/90 patients (training set), the T1 relaxation rates of remote myocardium and dense myocardial scar were linearly regressed to that of blood. The learned linear relationship was applied to 30/90 patients (validation set) to identify the remote myocardium and dense scar, and to normalize the LGE signal intensity to a range from 0 to 100 %. A 50 % threshold was applied to identify myocardial scar. In the validation set, two observers independently performed manual scar identification, annotated reference regions for the full-width-half-maxima (FWHM) and standard deviation (SD) method, and analyzed the LL sequence for the proposed method. Compared with the manual, FWHM, and SD methods, the proposed method demonstrated the highest inter-class correlation coefficient (0.997) and Dice overlap index (98.7 ± 1.3 %) between the two observers. The proposed method also showed excellent agreement with the gold-standard manual scar identification, with a Dice index of 89.8 ± 7.5 and 90.2 ± 6.6 % for the two observers, respectively. Combined analysis of LL and LGE sequences leads to objective and reproducible myocardial scar identification in post-infarction patients.
Authors:
Qian Tao; Hildo J Lamb; Katja Zeppenfeld; Rob J van der Geest
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-19
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  -     ISSN:  1875-8312     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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