Document Detail


Myocardial resistance assessed by guidewire-based pressure-temperature measurement: in vitro validation.
MedLine Citation:
PMID:  15103605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By injecting a few cubic centimeters of saline into the coronary artery and using thermodilution principles, mean transit time (T(mn)) of the injectate can be calculated and is inversely proportional to coronary blood flow. Because microvascular resistance equals distal coronary pressure (P(d)) divided by myocardial flow, the product P(d). T(mn) provides an index of myocardial resistance (IMR). In this in vitro study in a physiologic model of the coronary circulation, we compared IMR to true myocardial resistance (TMR) at different degrees of myocardial resistance and at different degrees of epicardial stenosis. Absolute blood flow was varied from 42 to 203 ml/min and TMR varied from 0.39 to 1.63 dynes. sec/cm(5). Inverse mean transit time correlated well to absolute blood flow (R(2) = 0.93). Furthermore, an excellent correlation was found between IMR and TMR (R(2) = 0.94). IMR was independent on the severity of epicardial stenosis and thus specific for myocardial resistance. Thus, using one single guidewire, both fractional flow reserve and IMR can be measured simultaneously as indexes of epicardial and microvascular disease, respectively, enabling separate assessment of both coronary arterial and microvascular disease.
Authors:
Wilbert Aarnoudse; Petra van den Berg; Frans van de Vosse; Maartje Geven; Marcel Rutten; Mark Van Turnhout; William Fearon; Bernard de Bruyne; Nico Pijls
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  62     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-22     Completed Date:  2004-11-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-63     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Affiliation:
Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Body Temperature / physiology*
Coronary Circulation / physiology
Coronary Stenosis / physiopathology
Humans
Models, Cardiovascular
Myocardium / chemistry*
Pericardium / physiopathology
Severity of Illness Index
Statistics as Topic
Vascular Resistance / physiology*
Ventricular Pressure / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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