| Myocardial reperfusion injury in neuronal nitric oxide synthase deficient mice. | |
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MedLine Citation:
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PMID: 11107506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A substantial amount of data suggesting that endothelial cell nitric oxide synthase (eNOS) plays a cardioprotective role in animal models of ischemia-reperfusion injury has amassed. We have previously demonstrated that eNOS-deficient (-/-) mice exhibit significantly larger myocardial infarcts than do wild-type mice. Few investigations have examined the neuronal form of nitric oxide synthase in the heart. The two constitutive isoforms have been demonstrated to play differing roles in studies of cerebral ischemia-reperfusion. OBJECTIVE: To characterize the role of neuronal nitric oxide synthase (nNOS) in myocardial ischemia-reperfusion injury. METHODS: Wild-type and nNOS -/- mice were subjected to 20 min of coronary artery occlusion and 120 min of reflow. RESULTS: We found no significant difference between the two groups in terms of infarct size. Microscopic cross-sections from both groups were examined for infiltration of polymorphonuclear leukocyte. Hearts of nNOS -/- mice exhibited significantly (P < 0.05) more polymorphonuclear leukocytes than did hearts of wild-type mice. CONCLUSION: Despite the fact that eNOS plays a cardioprotective role in the ischemic-reperfused myocardium, we observed no change in size of myocardial infarcts when nNOS was genetically disrupted. |
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Authors:
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S P Jones; W G Girod; P L Huang; D J Lefer |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Coronary artery disease Volume: 11 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-02-21 Completed Date: 2001-03-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 593-7 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Male Mice Mice, Inbred C57BL Mice, Transgenic Myocardial Reperfusion Injury / etiology*, physiopathology Myocardium / pathology Nerve Tissue Proteins / deficiency*, physiology Neutrophils / physiology Nitric Oxide Synthase / deficiency*, physiology Nitric Oxide Synthase Type I |
| Grant Support | |
ID/Acronym/Agency:
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P01 DK 43785/DK/NIDDK NIH HHS; R01 HL 60849/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type I; EC 1.14.13.39/Nos1 protein, mouse |
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