Document Detail

Myocardial reperfusion in acute experimental ischemia. Beneficial effects of prior treatment with steroids.
MedLine Citation:
PMID:  1260988     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that prior steroid administration may enhance the mechanical and metabolic response to myocardial reperfusion, regional myocardial function (Hg-in-silastic length gauges), transmyocardial lactate balance and K+ difference were measured in 12 control and 13 treated (30 mg/kg methyl-prednisolone, 30 to 60 min postocclusion) dogs. At three hours of ischemia, systolic shortening in the ischemic segment was greater in treated dogs (40.6% vs. 12%, P less than 0.05), while both lactate balance and K+ arteriovenous difference became positive. Lactate balance and K+ difference remained negative in the untreated animals. After three hours of occlusion and one hour of reperfusion, recovery of shortening was significantly greater in the treated animals (75.9 vs. 31.6%, P less than 0.05). In addition, while lactate balance remained negative among the control dogs, it further improved in the treated dogs. Thus, steroid administration during experimental coronary occlusion impedes the progression of ischemia and is additive to reperfusion in reversing ischemic dysfunction.
P L da Luz; J S Forrester; H L Wyatt; G A Diamond; M Chag; H J Swan
Related Documents :
2278398 - Active drainage of cardiac lymph in relation to reduction in size of myocardial infarct...
973888 - Pathology of acute myocardial infarction with particular reference to occlusive coronar...
75688 - Experimental myocardial infarction. xvi. the detection of inotropic contractile reserve...
1088028 - Reversal of acute myocardial ischemia in closed chest animals by retrograde perfusion o...
1462908 - Noninvasive assessment of systolic and diastolic left ventricular function in patients ...
14648038 - Morphologic study of left ventricular bands.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  53     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  847-52     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Coronary Circulation*
Coronary Disease / complications*,  metabolism,  physiopathology
Heart / physiopathology
Lactates / metabolism
Methylprednisolone / administration & dosage,  pharmacology,  therapeutic use*
Myocardial Infarction / prevention & control*
Myocardium* / metabolism
Potassium / metabolism
Reg. No./Substance:
0/Lactates; 7440-09-7/Potassium; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of isometric exercise on the end-diastolic pressure, volumes, and function of the left ventr...
Next Document:  Effect of intra-aortic balloon counterpulsation on the motion and perfusion of acutely ischemic myoc...