| Myocardial protection from ischemic arrest: potassium and verapamil cardioplegia. | |
| | |
MedLine Citation:
|
PMID: 7212077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Prolonged normothermic myocardial ischemic arrest results in myocardial dysfunction. This study has investigated the technique of preserving myocardial function by a single bolus intracoronary infusion of combination potassium and verapamil at the onset of ischemic arrest. Sixty-one dogs underwent cardiopulmonary bypass with 60 min of ischemic arrest: 25 received no myocardial protection, 12 received a single intracoronary bolus of KCl, 12 received combination verapamil and KCl, and 12 received verapamil alone. Following the ischemic arrest, hearts protected by combination of potassium and verapamil demonstrated better survival evidenced by the ability of all 12 dogs to resume normal hemodynamic function. The hemodynamic function in the combination potassium and verapamil group also demonstrated better cardiac output, left ventricular dF/dt, and myocardial segment shortening than survivors in the other groups. Subsarcolemmal (SSL) and intermyofibrillar IMF) mitochondria were isolated from these hearts and function evaluated. NADH-linked oxygen consumption was impaired as was calcium transport in the SSL from unprotected ischemic hearts. Intermyofibrillar mitochondria were not different from control or sham. The hearts protected by verapamil and potassium demonstrated normal mitochondrial function. |
| | |
Authors:
|
W W Pinsky; R M Lewis; J B McMillin-Wood; H Hara; C J Hartley; P C Gillette; M L Entman |
Related Documents
:
|
20449907 - Intra-arrest rapid head cooling improves postresuscitation myocardial function in compa... 20516307 - Small area variations in out-of-hospital cardiac arrest: does the neighborhood matter? 16969737 - Mechanisms of injury in hypoxic-ischemic encephalopathy: implications to therapy. 2064097 - Limitations of open-chest cardiac massage after prolonged, untreated cardiac arrest in ... 9124907 - Efficacy of a simple left atrial procedure for chronic atrial fibrillation in mitral va... 1711967 - When is drug therapy warranted to prevent sudden cardiac death? |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 240 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1981 Mar |
Date Detail:
|
Created Date: 1981-05-26 Completed Date: 1981-05-26 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H326-35 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiomyopathies / prevention & control Cardiopulmonary Bypass Dogs Heart Arrest, Induced* Mitochondria, Heart / metabolism* Myocardium / metabolism* Oxygen Consumption Potassium / pharmacology* Verapamil / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-00181/HL/NHLBI NIH HHS; HL-22512/HL/NHLBI NIH HHS; HL-23161/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
52-53-9/Verapamil; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regression of cardiac oxygen consumption on ventricular pressure-volume area in dog.
Next Document: Preload changes modify systolic pressure-diameter relations in the conscious dog.