Document Detail


Myocardial protection from ischemic arrest: potassium and verapamil cardioplegia.
MedLine Citation:
PMID:  7212077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolonged normothermic myocardial ischemic arrest results in myocardial dysfunction. This study has investigated the technique of preserving myocardial function by a single bolus intracoronary infusion of combination potassium and verapamil at the onset of ischemic arrest. Sixty-one dogs underwent cardiopulmonary bypass with 60 min of ischemic arrest: 25 received no myocardial protection, 12 received a single intracoronary bolus of KCl, 12 received combination verapamil and KCl, and 12 received verapamil alone. Following the ischemic arrest, hearts protected by combination of potassium and verapamil demonstrated better survival evidenced by the ability of all 12 dogs to resume normal hemodynamic function. The hemodynamic function in the combination potassium and verapamil group also demonstrated better cardiac output, left ventricular dF/dt, and myocardial segment shortening than survivors in the other groups. Subsarcolemmal (SSL) and intermyofibrillar IMF) mitochondria were isolated from these hearts and function evaluated. NADH-linked oxygen consumption was impaired as was calcium transport in the SSL from unprotected ischemic hearts. Intermyofibrillar mitochondria were not different from control or sham. The hearts protected by verapamil and potassium demonstrated normal mitochondrial function.
Authors:
W W Pinsky; R M Lewis; J B McMillin-Wood; H Hara; C J Hartley; P C Gillette; M L Entman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  240     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H326-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / prevention & control
Cardiopulmonary Bypass
Dogs
Heart Arrest, Induced*
Mitochondria, Heart / metabolism*
Myocardium / metabolism*
Oxygen Consumption
Potassium / pharmacology*
Verapamil / pharmacology*
Grant Support
ID/Acronym/Agency:
HL-00181/HL/NHLBI NIH HHS; HL-22512/HL/NHLBI NIH HHS; HL-23161/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
52-53-9/Verapamil; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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