Document Detail

Myocardial protection during ischemic cardiac arrest. The importance of magnesium in cardioplegic infusates.
MedLine Citation:
PMID:  661356     Owner:  NLM     Status:  MEDLINE    
The increasing use of coronary infusates for the protection of the human heart drug ischemic cardiac arrest has placed great emphasis on the need for a rational and safe formulation of any infusion solution. Using a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest, we have found magnesium to be a highly effective component of protective infusates which can be additive to hypothermia and other protective agents. However, the concentration of magnesium bears a complex relationship to the degree of protection, a fact which stresses the need for the establishment of the correct concentration for optimal protection.
D J Hearse; D A Stewart; M V Braimbridge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  75     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  877-85     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Body Temperature
Chlorides / pharmacology
Coronary Circulation*
Dose-Response Relationship, Drug
Heart Arrest, Induced / methods*
Heart Rate
Hypothermia, Induced
Magnesium Sulfate / administration & dosage,  pharmacology*
Myocardium / metabolism*
Time Factors
Reg. No./Substance:
0/Chlorides; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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