| Myocardial protection during ischemic cardiac arrest. The importance of magnesium in cardioplegic infusates. | |
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MedLine Citation:
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PMID: 661356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The increasing use of coronary infusates for the protection of the human heart drug ischemic cardiac arrest has placed great emphasis on the need for a rational and safe formulation of any infusion solution. Using a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest, we have found magnesium to be a highly effective component of protective infusates which can be additive to hypothermia and other protective agents. However, the concentration of magnesium bears a complex relationship to the degree of protection, a fact which stresses the need for the establishment of the correct concentration for optimal protection. |
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Authors:
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D J Hearse; D A Stewart; M V Braimbridge |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 75 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 1978 Jun |
Date Detail:
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Created Date: 1978-08-14 Completed Date: 1978-08-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 877-85 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Body Temperature Chlorides / pharmacology Coronary Circulation* Dose-Response Relationship, Drug Heart Arrest, Induced / methods* Heart Rate Hypothermia, Induced Magnesium Sulfate / administration & dosage, pharmacology* Male Myocardium / metabolism* Perfusion Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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