Document Detail

Myocardial production of C-type natriuretic peptide in chronic heart failure.
MedLine Citation:
PMID:  12566368     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: C-type natriuretic peptide (CNP) is a vasodilator produced by the vascular endothelium. It shares structural and physiological properties with the cardiac hormones atrial natriuretic peptide and brain natriuretic peptide (BNP), but little is known about its pathophysiological role in chronic heart failure (CHF). We assessed the hypothesis that CNP is produced by the heart in patients with CHF. METHODS AND RESULTS: Myocardial CNP production was determined (difference in plasma levels between the aortic root and coronary sinus [CS]) in 9 patients undergoing right and left heart catheterization as part of their CHF assessment (all male, age 59+/-9 years; New York Heart Association class 2.2+/-0.1; left ventricular ejection fraction 29+/-5%; creatinine 105+/-8 micro mol/L [all values mean+/-SEM]). BNP, established as originating from myocardium, was assessed from the same samples as a positive control. Analyses were performed by a blinded operator using a standard competitive radioimmunoassay kit (Peninsula Laboratories, Bachem Ltd UK). A step-up (29%) in plasma CNP concentration was found from the aorta to the CS (3.55+/-1.53 versus 4.59+/-1.54 pg/mL, respectively; P=0.035). The mean increase in CNP was 0.90+/-0.35 pg/mL (range 0.05 to 2.80 pg/mL). BNP levels increased by 57% from aorta to CS (86.0+/-20.5 versus 135.0+/-42.2 pg/mL; P=0.01). CS CNP levels correlated with mean pulmonary capillary wedge pressure (r=0.82, P=0.007). CONCLUSIONS: We have shown that CNP is produced by the heart in patients with CHF. Although further evaluation is required to define its full pathophysiological role in this condition, CNP may represent an important new local mediator in the heart.
Paul R Kalra; Jonathon R Clague; Aidan P Bolger; Stefan D Anker; Phillip A Poole-Wilson; Allan D Struthers; Andrew J Coats
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  107     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  571-3     Citation Subset:  AIM; IM    
Clinical Cardiology, National Heart and Lung Institute, London, UK.
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MeSH Terms
Atrial Natriuretic Factor / blood
Blood Pressure
Chronic Disease
Heart Catheterization
Heart Failure / blood*,  complications
Heart Rate
Middle Aged
Natriuretic Peptide, Brain / blood
Natriuretic Peptide, C-Type / blood*
Pulmonary Wedge Pressure
Stroke Volume
Ventricular Dysfunction, Left / complications
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain; 127869-51-6/Natriuretic Peptide, C-Type; 85637-73-6/Atrial Natriuretic Factor

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