Document Detail


Myocardial postconditioning: Next step to cardioprotection.
MedLine Citation:
PMID:  21975801     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Myocardial ischemia is a condition in which lack of blood flow to the cardiac muscle occurs resulting in deficient oxygen and nutrient supply to the heart. The restoration of blood flow to an organ or tissue is termed reperfusion. Brief episodes of ischemia and reperfusion given after prolonged ischemia and at the onset of reperfusion denotes postconditioning. Myocardial postconditioning is a phenomenon in which myocardium from lethal ischemia-reperfusion injury is protected. However, numerous experimental studies reveal that the cardioprotective effects of postconditioning are suppressed in various pathological states. This review critically discusses the mechanisms involved in the cardioprotective effects of postconditioning and factors affecting the cardioprotective potential of myocardial postconditioning.
Authors:
Ankur Rohilla; Seema Rohilla; Ashok Kushnoor
Publication Detail:
Type:  Journal Article     Date:  2011-10-06
Journal Detail:
Title:  Archives of pharmacal research     Volume:  34     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1409-15     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, Shri Gopi Chand, Group of Institutions, Baghpat, 250609, UP, India, ankurrohilla1984@rediffmail.com.
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