| Myocardial perfusion scintigraphy with adenosine: does it impair the left ventricular ejection fraction obtained with gated SPECT? | |
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MedLine Citation:
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PMID: 18209525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to assess whether adenosine impairs left ventricular ejection fraction (LVEF) obtained with gated SPECT in patients with a normal myocardial perfusion scintigram. MATERIALS AND METHODS: This prospective study included 160 consecutive patients with a normal myocardial perfusion scintigraphy (MPS), who were stressed with either exercise (n = 64) or with adenosine (n = 96). Student t-test or chi test was used to compare patient's characteristics and functional parameters. Linear regression analyses were used to assess which patient characteristics had an independent significant influence on LVEF. RESULTS: Functional parameters at rest were not significantly different between the adenosine group and the exercise stress group. However at stress, these functional parameters were significantly different. LVEF in the adenosine group decreased by -2.5%, whereas in the exercise group LVEF increased by 2.2% (P = 0.001). Moreover, in 36.5% of the patients a decrease in the LVEF of more than 5% was observed in the group stressed with adenosine compared with 15.6% in the exercise group (P = 0.002). In regression analysis, adenosine (P = 0.001) was selected as an independent significant correlate of a decrease in LVEF. CONCLUSION: Adenosine seems to impair the LVEF obtained with gated SPECT in patients with a normal perfusion scintigram. Further evaluation is necessary to elucidate how adenosine exerts this effect and also, whether this finding has a prognostic value in patients with a normal perfusion scintigram. |
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Authors:
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Niels Brinkman; Petra Dibbets-Schneider; Arthur J H A Scholte; Marcel P M Stokkel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 33 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-22 Completed Date: 2008-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 89-93 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Leiden University Medical Centre, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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diagnostic use* Chi-Square Distribution Coronary Disease / radionuclide imaging* Diabetes Complications / radionuclide imaging Exercise Test* Female Humans Linear Models Male Middle Aged Prospective Studies Stroke Volume Tomography, Emission-Computed, Single-Photon* Ventricular Dysfunction, Left / radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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