Document Detail


Myocardial perfusion during exercise in endurance-trained and untrained humans.
MedLine Citation:
PMID:  17522118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because of technical challenges very little is known about absolute myocardial perfusion in humans in vivo during physical exercise. In the present study we applied positron emission tomography (PET) in order to 1) investigate the effects of dynamic bicycle exercise on myocardial perfusion and 2) clarify the possible effects of endurance training on myocardial perfusion during exercise. Myocardial perfusion was measured in endurance-trained and healthy untrained subjects at rest and during absolutely the same (150 W) and relatively similar [70% maximal power output (W(max))] bicycle exercise intensities. On average, the absolute myocardial perfusion was 3.4-fold higher during 150 W (P < 0.001) and 4.9-fold higher during 70% W(max) (P < 0.001) than at rest. At 150 W myocardial perfusion was 46% lower in endurance-trained than in untrained subjects (1.67 +/- 0.45 vs. 3.00 +/- 0.75 ml x g(-1) x min(-1); P < 0.05), whereas during 70% W(max) perfusion was not significantly different between groups (P = not significant). When myocardial perfusion was normalized with rate-pressure product, the results were similar. Thus, according to the present results, myocardial perfusion increases in parallel with the increase in working intensity and in myocardial work rate. Endurance training seems to affect myocardial blood flow pattern during submaximal exercise and leads to more efficient myocardial pump function.
Authors:
Marko S Laaksonen; Kari K Kalliokoski; Matti Luotolahti; Jukka Kemppainen; Mika Teräs; Heikki Kyröläinen; Pirjo Nuutila; Juhani Knuuti
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-23
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  293     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R837-43     Citation Subset:  IM    
Affiliation:
Turku PET Centre, University of Turku, Turku, Finland. marko.laaksonen@miun.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Coronary Circulation / physiology*
Exercise / physiology
Exercise Test / methods*
Heart / physiology,  radionuclide imaging*
Humans
Male
Physical Endurance / physiology*
Physical Fitness / physiology
Positron-Emission Tomography / methods*
Rest / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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